Circulating small extracellular vesicles microRNAs plus CA-125 for treatment stratification in advanced ovarian cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Xiaofang;Liu, Mu;Sun, Lijuan;Cao, Yumei;Tan, Shanmei;...

通讯作者：

Tang, J

作者机构：

[Tang, J; Wan, Ziqing; Zhou, Xiaofang; Tang, Jie; Liu, Mu] Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Dept Gynecol Oncol,Xiangya Sch Med, Changsha 410013, Peoples R China.

[Cao, Yumei; Sun, Lijuan] Cent Hosp Shaoyang, Dept Gynecol & Obstet, Shaoyang 422000, Peoples R China.

[Luo, Guangxia; Tan, Shanmei] Univ South China, Peoples Hosp Huaihua 1, Dept Gynecol & Obstet, Affiliated Huaihua Hosp, Huaihua 418000, Peoples R China.

[Liu, Tingting] First Peoples Hosp Changde, Dept Gynecol & Obstet, Changde 415000, Peoples R China.

[Yao, Ying; Xiao, Wangli] First Peoples Hosp Yueyang, Dept Gynecol & Obstet, Yueyang 414000, Peoples R China.

通讯机构：

[Tang, J ] C

Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Dept Gynecol Oncol,Xiangya Sch Med, Changsha 410013, Peoples R China.

Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Dept Gynecol Oncol,Hunan Gynecol Canc Res Ctr,Aff, 283 Tongzipo Rd, Changsha 410013, Peoples R China.

语种：

英文

关键词：

Ovarian cancer;Residual disease;Small extracellular vesicles;microRNA;Prediction model

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2023

卷：

期：

页码：

1-19

DOI：

10.1186/s12967-023-04774-4

基金类别：

This work was supported by Grants from the General Project of Natural Science Foundation of Hunan Province (No. 2020JJ4051); Promotion Project of Health Suitability Program in Health Department of Hunan Province (No. WZ2020-15); Science and Technology Innovation Program of Hunan Province (No. 2020SK51101); Hunan Cancer Hospital Climbing Fund (No. ZX2020004); Capacity Building Project of Central Subsidy Medical and Health Institutions (No. 20201127-1001); Key Specialty Construction Project in Hunan Province (No. 20210826-1004); General Project in Health Department of Hunan Province (No. 202205015388).

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本校为其他机构

摘要：

BACKGROUND: No residual disease (R0 resection) after debulking surgery is the most critical independent prognostic factor for advanced ovarian cancer (AOC). There is an unmet clinical need for selecting primary or interval debulking surgery in AOC patients using existing prediction models. METHODS: RNA sequencing of circulating small extracellular vesicles (sEVs) was used to discover the differential expression microRNAs (DEMs) profile between any residual disease (R0, n = 17) and no residual disease (non-R0, n = 20) in AOC patients. We fur...

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Circulating small extracellular vesicles microRNAs plus CA-125 for treatment stratification in advanced ovarian cancer

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