期刊论文

Study on dose accumulation in IMRT for left breast cancer patients after radical mastectomy

中文

中华放射医学与防护杂志

0254-5098

2019

39

12

910-915

10.3760/cma.j.issn.0254-5098.2019.12.006

山东省重点研发计划项目 (2018GSF118048)。

本校为第一机构

目的通过形变配准及刚性配准进行左侧乳腺癌放疗中靶区及危及器官剂量累加的研究,探讨二者受量的变化规律。方法回顾分析16例女性左侧乳腺癌根治术后患者,靶区包括锁上淋巴结引流区加胸壁,均采用6 MV X射线调强放疗(IMRT)。所有患者均接受定位、二程CT扫描,在定位图像(CT1)上制定放疗计划为Planl,在二程定位图像(CT2)上制定放疗计划为Plan2。利用Velocity软件将Plan2的剂量进行刚性、形变配准到CT1剂量累加后获得Planrigid、Plan-deform。比较4个计划中靶区及危及器官的剂量学差异。结果CT2比CT1的CTV体积平均缩小6.64%;形变后靶区剂量均匀性指数(HI)提高23.05%,而形变后心脏、左、右肺戴斯相似...

Objective To investigate the changes of accumulated dose in target area and organs at risk ( OARs) for radiotherapy of left breast cancer by deformable and rigid image registration. Methods A total of 16 left breast cancer patients treated with 6 MV X-ray IMRT were analyzed retrospectively. All targets included the lymph node drainage area and the chest wall. All patients underwent simulation of the primary positioning and repositioning to obtain CT images. Primary and secondary treatment plans were developed using primary positioning CT ( CT1)...