期刊论文

The impact of heartbeat on the left ventricular myocardial and the left anterior descending coronary arterial dosimetry following intensity modulated radiotherapy for left-sided breast cancer

中文

中华放射医学与防护杂志

0254-5098

2018

38

10

747-750

10.3760/cma.j.issn.0254-5098.2018.10.005

国家自然科学基金（81301936） 山东省重点研发计划（2018GSF118048）

本校为第一机构

目的研究左侧乳腺癌调强放射治疗(IMRT)中,心跳对左心室肌(mLV)及左前降支(LAD)剂量评估的影响。方法选取15例女性患者平静吸气屏气下的心电门控(ECG-gated)4D-CT图像,参照心动周期以5%间隔进行图像重建,重建0~95%共20个时相的图像。分别勾画mLV及LAD。基于0%时相的图像进行左侧乳腺癌IMRT计划设计。统计各时相mLV的体积并计算相似性指数(dice similarity coefficient, DSC);计算LAD及mLV剂量-体积指标的变化范围。结果mLV的DSC变化率最大可达472.07%,其平均变化率约为体积变化率的8倍。mLV的体积与DSC在最大、最小值之间差异均具有统计学意义(t=-6.585、 -28.870, P

Objective To study the impact of heartbeat on the left ventricular myocardial (mLV) and the left anterior descending (LAD) coronary arterial dosimetry following intensity modulated radiotherapy (IMRT) for left-sided breast carcinoma. Methods A total of 15 female patients who received electrocardiography gated 4D-CT scan in inspiratory breathing-holding were enrolled. According to cardiac cycle, 20 time-phase images were reconstructed from 0 to 95% at 5% interval. Then, the mLV and the LAD were delineated respectively and the IMRT plans of the left breast carcinoma were generated based on 0% ph...