Association of PD-L1 gene rs4143815 C>G polymorphism and human cancer susceptibility: A systematic review and meta-analysis

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成果类型：

期刊论文

作者：

Zou, Ju;Wu, Daichao*;Li, Tao;Wang, Xianwen;Liu, Yan;...

通讯作者：

Wu, Daichao;Tan, Sijie

作者机构：

[Liu, Yan; Zou, Ju] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Dept Parasitol,Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Tan, Sijie; Wu, Daichao] Univ South China, Hengyang Med Coll, Dept Histol & Embryol, Inst Clin Anat & Reprod Med, Hengyang 421001, Hunan, Peoples R China.

[Li, Tao; Wang, Xianwen] Univ South China, Hengyang Med Coll, Grade 2015 Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Wu, Daichao; Tan, SJ] Univ South China, Hengyang Med Coll, Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, DC; Tan, SJ] U

Univ South China, Hengyang Med Coll, Inst Clin Anat & Reprod Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

biological marker;programmed death 1 ligand 1;CD274 protein, human;programmed death 1 ligand 1;bladder cancer;cancer risk;cancer susceptibility;colorectal cancer;disease marker;esophageal squamous cell carcinoma;genetic association;genetic linkage;genetic polymorphism;genetic variability;human;liver cell carcinoma;meta analysis;non small cell lung cancer;ovary cancer;Review;single nucleotide polymorphism;stomach cancer;systematic review;genetic predisposition;genetics;genotype;neoplasm;odds ratio;B7-H1 Antigen;Genetic Predisposition to Disease;Genotype;Humans;Neoplasms;Odds Ratio;Polymorphism, Single Nucleotide

期刊：

PATHOLOGY RESEARCH AND PRACTICE

ISSN：

0344-0338

年：

2019

卷：

215

期：

页码：

229-234

DOI：

10.1016/j.prp.2018.12.002

基金类别：

The study was supported by Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City ( 2017KJ182 ). ST was also partially supported by a grant from University of South China ( 2014XQD22 ) and a fellowship from Chinese Scholarship Council ( 201608430251 ) while writing this manuscript. TL and XW were supported by a College Students' research learning and innovative experiment program grant from University of South China (No. 2018XJXZ159 and No. 2018XJXZ161 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Programmed death ligand 1(PD-L1) mediated immune escape play important roles in the development of cancer. The gene polymorphism of PD-L1, in particular rs4143815 C > G, has been associated with the cancer risks, but with conflicting results. Therefore, this meta-analysis was aimed to assess the association between rs4143815 C > G and cancer susceptibility. A systematic literature search was performed to select the studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Eleven e...

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Association of PD-L1 gene rs4143815 C>G polymorphism and human cancer susceptibility: A systematic review and meta-analysis

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