期刊论文

Tang, Zhi-han;Liu, LS

英文

Clinica Chimica Acta

0009-8981

2018

483

192-196

10.1016/j.cca.2018.04.040

This work was supported by the grants from the National Natural Science Foundation of China (81770454), the Natural Science Foundation of Hunan province (2018JJ2343, 2015JJ4097), the Key Project of the Education Department of Hunan Province (15A137), the Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education (CQKLBST-2014-002, CQKLBST-2015-004), and by the first-class discipline in Hunan Province.

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Atherosclerosis is characterized by chronic inflammation and lipid accumulation in arterial walls, resulting in several vascular events. Proprotein convertase subtilisin kexin 9 (PCSK9), a serine protease, has a pivotal role in the degradation of hepatic low-density lipoprotein receptor (LDLR). It can increase plasma concentrations of low-density lipoprotein cholesterol and affect lipid metabolism. Recently, PCSK9 has been found to accelerate atherosclerosis via mechanisms apart from that involving the degradation of LDLR, with an emerging role in regulating the inflammatory response in athero...