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N6-methyladenine rna modification (M6a): An emerging regulator of metabolic diseases

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成果类型:
期刊论文
作者:
Zhong, Hui;Tang, Hui-Fang;Kai, Yin*
通讯作者:
Kai, Yin
作者机构:
[Zhong, Hui; Kai, Yin] Univ South China, Meng Yang Med Sch, Res Lab Translat Med, Hengyang 421001, Peoples R China.
[Kai, Yin] Guilin Med Univ, Affliated Hosp 2, Guangxi Key Lab Diabet Syst Med Guilin Med Univ, Guilin 541100, Peoples R China.
[Tang, Hui-Fang] Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang, Hunan, Peoples R China.
通讯机构:
[Kai, Yin] G
[Kai, Yin] U
Guilin Med Univ, Affliated Hosp 2, Guangxi Key Lab Diabet Syst Med Guilin Med Univ, Guilin 541100, Peoples R China.
Univ South China, Meng Yang Med Sch, Res Lab Translat Med, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
N6-adenine methylation;metabolic diseases;obesity;type 2 diabetes mellitus;cardiovascular diseases.
期刊:
CURRENT DRUG TARGETS
ISSN:
1389-4501
年:
2020
卷:
21
期:
11
页码:
1056-1067
基金类别:
The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81970390, 81470569), the Natural Sciences Foundation of Hunan Province, China (2018JJ2341), and the National college students innovation and entrepreneurship fund (201710555015, 201710555010).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
N6-methyladenine RNA modification (m6A) is an RNA methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine (A), which is the most common chemical modification of eukaryotic messenger RNA (mRNA). Recently, m6A has been found to play an important role in the dynamic regulation of RNA, which is crucial for some physiological and pathophysiological processes such as adipogenesis, cell differentiation, and the immune/inflammatory response. Metabolic diseases are a series of chronic inflammatory disorders caused by metabolic dysfunction of proteins, glucos...

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