期刊论文

The mechanism and function of Schistosoma egg antigens in regulating immune cells

中文

微生物学免疫学进展

1005-5673

2022

50

03

77-81

10.13309/j.cnki.pmi.2022.03.012

国家自然科学基金(81101274)。

本校为第一机构

血吸虫病主要由虫卵沉积于肝肠组织引起免疫病理性疾病。虫卵的分泌物和排泄物都可以作为抗原物质，通过多种机制刺激巨噬细胞、树突状细胞、中性粒细胞、T细胞和调节性B细胞（regulatory B cell, Breg细胞）等分泌细胞因子和趋化因子，从而刺激宿主的免疫应答，影响虫卵肉芽肿和纤维化的发生、发展。有些虫卵抗原可以诱导M2型巨噬细胞、2型辅助性T细胞（type 2 helper T cell, Th2细胞）、调节性T细胞（regulatory T cell, Treg细胞）和Breg细胞的分化，可以用于某些炎症疾病和免疫疾病的治疗。现主要对虫卵抗原诱导免疫细胞的机制和作用作一概述。

Schistosomiasis is mainly caused by the deposition of Schistosoma eggs in the liver and intestine tissues to trigger immunopathological diseases.The secretions and excrements of eggs can be used as antigens to stimulate macrophages,dendritic cells,neutrophils,T cells and Breg cells secrete cytokines and chemokines through various mechanisms,thereby regulating the host’s immune response and affecting the occurrence and development of egg granuloma and fibrosis.Some egg antigens can induce the differentiation of M2 type macrophages and Th2,Treg ...