期刊论文

中文

微生物学免疫学进展

1005-5673

2019

47

3

81-85

10.13309/j.cnki.pmi.2019.03.014

“特殊病原体防控”湖南省科技厅重点试验室资助项目[湘科计字(2014)5号] 湖南省分子靶标新药研究协同创新中心资助项目[湘教通(2014)405号、(2015)351号] 南华大学大学生研究性学习和创新性试验计划项目(2018XJXZ384).

本校为第一机构

胃癌(gastric cance, GC)是世界范围内最常见的恶性肿瘤之一,其病死率在癌症中位居第二。GC的发病机制目前尚不明确,其发病机制与多种因素有关,其中包括环境因素和遗传因素。幽门螺杆菌( Helicobacter pylori , Hp)感染是GC发生最为重要的环境因素之一。Hp感染在GC的发展过程中,会伴有一些基因和信号通路的异常。现就Hp感染引发GC过程中相关信号通路的异常,包括Hedgehog信号通路、Notch信号通路、Wnt/β-catenin信号通路以及上皮间质转化(epithelial-mesenchymal transition, EMT)相关信号通路等作一概述,为GC的预防及靶向治疗提供理论依据。

Gastric cancer (GC) is one of the most common malignant tumors in the world, and its mortality ranks second in cancer. Mechanism of GC pathogenesis is still unclear, and relies on multiple factors, including environmental and genetic characteristics. Helicobacter pylori (Hp) infection is one of the main environmental factors associated with the development of gastric cancer. The dysregulation of several genes and signaling pathways caused by Hp infection plays an important role in the development of gastric cancer. This article reviews the dysr...