To ensure its long-term survival in the infected hosts and to escape from the efficient host immune mechanism, chlamydia has developed a set of mechanisms, so as to perform a productive infection and multi-regulation on host cell , and result in the inhibition of apoptosis for host cell.In the early infection by chlamydia, caspase activation and related sig-nal transduction pathway are inhibited, then a series of changes occurred in mitochondria structure and function, the release of apoptosis factors decreased, finally, host cell apoptosis is inhibited.This review describes three aspects of a...