LIGHT/TNFSF14 is a new member of the tumor necrosis factor ( TNF) superfamily, which can regulate the function of immune system through binding with herpesvirus entry mediator ( HVEM) and lymphotoxin βreceptor ( LTβR) . Abundant studies revealed that LIGHT and its signal pathway participates in many aspects of pathologic processes , such as autoimmune diseases , graft versus host disease ( GVHD) , pathogen infection and tumorigenesis .Here the complicate r...
