Proliferating pancreatic beta-cells upregulate ALDH

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成果类型：

期刊论文

作者：

Liu, Yinglan;Jiang, Xiaoxin;Zeng, Yong;Zhou, Hui;Yang, Jing;...

通讯作者：

Cao, Renxian

作者机构：

[Cao, Renxian; Yang, Jing; Liu, Yinglan] Nanhua Univ, Affiliated Hosp 1, Dept Endocrinol, Hengyang 421001, Hunan Province, Peoples R China.

[Jiang, Xiaoxin] Nanhua Univ, Affiliated Hosp 1, Dept Clin Lab, Hengyang, Peoples R China.

[Zeng, Yong] Cent S Univ, Xiangya Med Coll, Affiliated Canc Hosp, Dept Pharm, Changsha, Hunan, Peoples R China.

[Zhou, Hui] Cent S Univ, Xiangya Med Coll, Affiliated Canc Hosp, Dept Chest Internal Med 1, Hengyang, Peoples R China.

[Cao, Renxian] Nanhua Univ, Affiliated Hosp 1, Dept Endocrinol, 69 Chuanshan Rd, Hengyang 421001, Hunan Province, Peoples R China.

通讯机构：

[Cao, Renxian] N

Nanhua Univ, Affiliated Hosp 1, Dept Endocrinol, 69 Chuanshan Rd, Hengyang 421001, Hunan Province, Peoples R China.

语种：

英文

关键词：

ALDH;Aldefluor;Beta-cell proliferation;Partial pancreatectomy

期刊：

Histochemistry and Cell Biology

ISSN：

0948-6143

年：

2014

卷：

142

期：

页码：

685-691

DOI：

10.1007/s00418-014-1248-4

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172542, 30870135]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

High levels of aldehyde dehydrogenase (ALDH) activity have been regarded as a specific feature of progenitor cells and stem cells. Hence, as an indicator of ALDH activity, aldefluor fluorescence has been widely used for the identification and isolation of stem and progenitor cells. ALDH activity was recently detected in embryonic mouse pancreas, and specifically and exclusively in adult centroacinar and terminal duct cells, suggesting that these duct cells may harbor cells of endocrine and exocrine differentiation potential in the adult pancreas. Here, we report the presence of aldefluor+ beta...

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Proliferating pancreatic beta-cells upregulate ALDH

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