In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniae

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成果类型：

期刊论文

作者：

Ou, G.;Liu, Y.;Tang, Y.;You, X.;Zeng, Y.;...

通讯作者：

Zhu, C.

作者机构：

[You, X.; Ou, G.; Yu, M.; Chen, L.; Zhu, C.; Zeng, Y.; Xiao, J.] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Coll Med, Inst Pathogen Biol, Hengyang City 421001, Hunan, Peoples R China.

[Liu, Y.; Wang, M.] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai 200433, Peoples R China.

[Tang, Y.] Shaoyang Med Coll, Shaoyang City, Hunan, Peoples R China.

[Zhu, C.] Univ South China, Dept Med Microbiol, 28 Changshengxi Rd, Hengyang City 421001, Hunan, Peoples R China.

通讯机构：

[Zhu, C.] U

Univ South China, Dept Med Microbiol, 28 Changshengxi Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Macrolide resistance;Mycoplasma pneumoniae;Subminimum inhibitory concentration

期刊：

HIPPOKRATIA

ISSN：

1108-4189

年：

2015

卷：

期：

页码：

57-62

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81441065]; Construct Program of the Key Discipline in Hunan Province, Hunan Provincial Key Laboratory for Special Pathogen Prevention and Control (Hunan Provincial Science and Technology Department) [2014-5]; Construct Program of the Key Discipline in Hunan Province, Hunan Provincial Key Laboratory for Special Pathogen Prevention and Control (Hunan Provincial Education Department) [2012-312]; Foundation of Hunan Technology Committee of China [2013FJ3067]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aim: This study aims to investigate the inducing effect of subminimum inhibitory concentrations of macrolide antibiotics on Mycoplasma pneumoniae (M. pneumoniae) resistance to drugs. Materials and Methods: One M. pneumoniae reference strain M129 (ATCC 29342) and 104 clinical isolates were incubated at 37°C for 6-8 days. Genomic DNA of M. pneumoniae was extracted using TIANamp Bacteria DNA kit and amplified by polymerase chain reaction (PCR). Results: Ten sensitive isolates obtained from 104 M. pneumoniae clinical isolates were induced by submi...

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In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniae

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