Midkine inhibits cholesterol efflux by decreasing ATP-binding membrane cassette transport protein A1 via adenosine monophosphate-activated protein kinase/mammalian target of rapamycin signaling in macrophages

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成果类型：

期刊论文

作者：

Ou, Han-xiao;Huang, Qin;Liu, Chu-hao;Xiao, Ji;Lv, Yun-cheng;...

通讯作者：

Mo, Zhong-cheng

作者机构：

[Li, Xuan; Huang, Qin; Liu, Chu-hao; Ou, Han-xiao] Univ South China, Hunan Prov Innovat Training Base Med Postgrad, Yueyang, Hunan, Peoples R China.

[Li, Xuan; Huang, Qin; Liu, Chu-hao; Ou, Han-xiao] Yueyang Women & Childrens Med Ctr, Yueyang, Hunan, Peoples R China.

[Lv, Yun-cheng; Ou, Han-xiao; Mo, Zhong-cheng] Guilin Med Univ, Guangxi Key Lab Excellence, Ctr Diabet Syst Med, Guilin, Peoples R China.

[Lv, Yun-cheng; Liu, Chu-hao; Mo, Zhong-cheng] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang, Peoples R China.

[Lei, Li-Ping; Xiao, Ji] Univ South China, Dept Anesthesiol, Affiliated Hosp 2, Hengyang, Peoples R China.

通讯机构：

[Mo, Zhong-cheng] G

Guilin Med Univ, Ctr Diabet Syst Med, Guangxi Key Lab Excellence, Fac Basic Med Sci, Guilin 541199, Guangxi, Peoples R China.

语种：

英文

关键词：

ABCA1;AMPK-mTOR signaling molecule;Atherosclerosis;Cholesterol efflux;Midkine

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2020

卷：

期：

页码：

217-225

DOI：

10.1253/circj.CJ-19-0430

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81670401]; Natural Sciences Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40248]; Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City [2017KJ182]; College Students' Research Learning and Innovative Experiment Plan of the University of South China [2018XJXZ137]; Chuanshan Talents Project of the University of South China

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Background: Midkine (MK), a heparin-binding protein, participates in multiple cellular processes, such as immunity, cellular growth and apoptosis. Overwhelming evidence indicates that MK plays an important role in various pathological processes, including chronic inflammation, autoimmunity, cancer, and infection. Recent studies demonstrated that MK may be involved in the development of atherosclerosis, yet the mechanism has not been fully explored. Therefore, this study aims to investigate the effect and mechanism of MK on macrophage cholestero...

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Midkine inhibits cholesterol efflux by decreasing ATP-binding membrane cassette transport protein A1 via adenosine monophosphate-activated protein kinase/mammalian target of rapamycin signaling in macrophages

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