Role of PCSK9 in lipid metabolism and atherosclerosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lin, Xiao-Long;Xiao, Le-Le;Tang, Zhi-Han;Jiang, Zhi-Sheng;Liu, Mi-Hua*

通讯作者：

Liu, Mi-Hua

作者机构：

[Lin, Xiao-Long] Guangzhou Med Univ, Hui Zhou Peoples Hosp 3, Dept Pathol, Huizhou City 516002, Guangdong, Peoples R China.

[Xiao, Le-Le] Huzhou Univ, Huzhou City 313000, Zhejiang, Peoples R China.

[Jiang, Zhi-Sheng; Tang, Zhi-Han; Liu, Mi-Hua] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Liu, Mi-Hua] Chongqing Med Univ, Affiliated Hosp 2, Ctr Lipid Res, Chongqing 400016, Peoples R China.

[Liu, Mi-Hua] Chongqing Med Univ, Affiliated Hosp 2, Key Lab Mol Biol Infect Dis, Minist Educ,Inst Viral Hepatitis,Dept Infect Dis, Chongqing 400016, Peoples R China.

通讯机构：

[Liu, Mi-Hua] C

Chongqing Med Univ, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.

语种：

英文

关键词：

Cholesterol;Lipoprotein receptors;Low density lipoprotein;Proprotein convertase subtilisin/kexin type 9

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2018

卷：

104

页码：

36-44

DOI：

10.1016/j.biopha.2018.05.024

基金类别：

This work was supported by grants from the National Natural Science Foundation of China ( 81600342 ) and Graduate Student Research innovation project of Hunan Province ( CX2013B397 ).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Elevated plasma low-density lipoprotein cholesterol (LDL-C) is an important risk factor for cardiovascular diseases. Statins are the most widely used therapy for patients with hyperlipidemia. However, a signiﬁcant residual cardiovascular risk remains in some patients even after maximally tolerated statin therapy. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new pharmacologically therapeutic target for decreasing LDL-C. PCSK9 reduces LDL intake from circulation by enhancing LDLR degradation and preventing LDLR recirculation to the...

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Role of PCSK9 in lipid metabolism and atherosclerosis

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