期刊论文

Expression of galectin-3 in patients with diabetic foot ulcer

中文

实用预防医学

1006-3110

2018

25

6

649-651

10.3969/j.issn.1006-3110.2018.06.003

国家自然科学基金（81570776）；

本校为其他机构

目的探讨糖尿病足溃疡（diabetic foot ulcer,DFU）患者伤口和血清中半乳糖凝集素3（galectin-3）的表达,以期阐明galectin-3和DFU的关系。方法选取2015年1月-2016年3月Wanger 1、2级的糖尿病足患者50例,另选取同期血糖正常的外伤患者20例为对照,分别取其足部伤口边缘组织及血清。对所有入选对象均行ELISA检测血清galectin-3浓度,Western-blot法检测伤口边缘组织galectin-3的表达水平。结果 ELISA结果显示DFU组血清galectin-3水平高于外伤对照组[（5.66±2.76）vs（4.25±1.94）ng/ml]（P=0.04）,Western-blot结果显示galectin-3在DFU组伤口边缘组织表达增强。结论 galectin-3在DFU患者中高表达...

Objective To investigate the expression of galectin-3 in wounds and sera of patients with diabetic foot ulcer（ DFU）so as to clarify the correlation between galectin-3 and DFU. Methods Fifty DFU patients with Wagner 1-2 stages and 20 wounded patients with normal blood glucose level（ serving as the control group） were enrolled to obtain their tissues from the edge of the foot wound and sera from January 2015 to March 2016. The serum concentration of galectin-3 was detected by ELISA,and the expression of galection-3 in the tissues was detected...