Diabetes osteoporosis (DOP) is a chronic complication of diabetes mellitus (DM) in skeletal system, which may be caused by many passible factors, including osmotic diuresis, accumulation of advanced glycosylation end products (AGEs), insuf- ficiency of the insulin - like growth factor - 1 ( IGF - 1 ), shortage of insulin, impacts of other diabetic complications and side ef- fects of anti - diabetic drugs. Because of the high morbidity and serious consequences, clinici...