期刊论文

中文

实用预防医学

1006-3110

2013

20

3

273-276

10.3969/j.issn.1006-3110.2013.03.006

本校为第一机构

目的 初步探讨双酚A对小鼠心脏组织的损伤作用. 方法 50只健康昆明(KM)小鼠,按体重随机分为5组,每组10只,雌雄各半.剂量组分别给予2.4、24、240、480 mg/kg双酚A灌胃染毒,对照组给予玉米油灌胃,每天1次,共28 d.试验中计算心脏脏器系数,荧光分光光度法测定心肌组织中Ca2+-ATP酶的活性,通过HE染色观察心肌组织病理变化. 结果 与对照组比较,染毒组小鼠Ca2+-ATP酶活性下降(P＜0.05),心脏脏器系数差异无统计学意义(P＞0.05).病理组织学检查可见心脏组织出现不同程度的改变,且随着剂量增加病理改变程度越显著.主要表现为心肌纤维排列疏松,间隙增宽,间质水肿,大量炎症细胞浸润,甚至心肌坏死.雌雄组之间...

Objective To preliminarily explore the heart injury by bisphenol-A（BPA） in mice.Methods Fifty healthy Kunming mice were randomly assigned into 5 groups with 10 mice,5 males and 5 females,for each group.The mice in the BPA-exposed groups were gavaged with 2.4,24,240 or 480mg/kg·bw BPA daily for 28 days,and the mice in the control group were gavaged with corn oil.At the end of the experiment,the organ coefficient of heart was calculated.The Ca2＋-ATPase activity in the cardiac tissue was determined.And the pathological changes in the cardiac t...