期刊论文

中文

实用预防医学

1006-3110

2012

19

2

165-168

10.3969/j.issn.1006-3110.2012.02.002

衡阳市科技局基金资助项目（衡科发2005-29）；

本校为第一机构

目的 观察原花青素(PC)对氨基脲(SEM)致雄性小鼠生殖毒性的拮抗作用及作用机制. 方法 50只KM雄性小鼠随机等分为5组:溶剂对照组、SEM染毒组、低、中、高剂量PC保护组.溶剂对照组灌胃去离子水；SEM染毒组先按56.25 mg/kg·bw SEM溶液灌胃染毒2周,再继续灌胃去离子水4周；3个剂量PC保护组,先分别灌胃PC 100、200、400 mg/kg· bw4周,继续分别灌胃同剂量SEM溶液2周；以上各组动物均按10 ml/kg· bw体积灌胃每日1次,连续灌胃6周剖杀,取其血液和组织器官检测生殖相关指标. 结果 PC保护组睾丸形态较SEM染毒组有所改善,且随PC剂量的加大改善较明显；低、中、高剂量PC组小鼠精子数、精子活动度较SEM组增...

Objective To observe the antagonism and its mechanism of procyanidins（PC） on semicarbazide（SEM） caused reproductive toxicity in male mice. Methods Fifty KM male mice were randomly divided into 5 groups： solvent control group,SEM exposure group,low-,medium-and high-dose PC protection groups.The mice of solvent control group were administrated intragastrically with deionized water.The mice of SEM exposure group were administered intragastrically with 56.25 mg/kg.bw SEM solution in the first two weeks,and then were dosed by gavage with deioni...