期刊论文

In Vitro Antibacterial Activities of Fluoroquinolones and Macrolides Against Ureaplasma urealyticumin

中文

实用预防医学

1006-3110

2008

15

5

1560-1562

10.3969/j.issn.1006-3110.2008.05.105

本校为第一机构

目的 研究解脲脲原体(Uu)对氟喹诺酮类和大环内酯类药物的敏感性,及不同pH值对大环内酯类药物在体外抗Uu最低抑菌浓度(MIC)的影响.方法 采用微量肉汤法检测了7种抗菌药物对72株Uu的MIC,及在pH值为6.0、6.5和6.9时,4种大环内脂药物抗Uu的MIC550.结果 72株Uu对左氧氟沙星、红霉素和罗红霉素耐药率分别为4.2%、15.3%和2.7%,未发现对加替沙星、司帕沙星、阿奇霉素和交沙霉素的耐药.司帕沙星和交沙霉素抗Uu活性最强,而红霉素和罗红霉素的抗Uu活性最差.当pH值6.0升到6.9时,红霉素的MIC50.下降8倍,而罗红霉素、阿奇霉素和交沙霉素MIC50分别下降4倍、16倍、8倍.结论 Uu对左氧氟沙星、红霉索和罗红霉素存...

Objective To determine the susceptibilities of clinical Ureaplasma urealyticum（Uu）isolates to fluoroquinolo- nes and macrolides, and to explore the effects of medium pH on MIC of macrolides against Uu in vitro. Methods Seven antimicrobial MICs against 72 strains of Uu, and MICs0 of four macrolides in pH at 6.0, 6.5 and 6.9 were assessed by broth microdilution method. Results The resistant rates of 72 strains of Uu were： levofloxacin 4.2%, erythromycin 15.3 %, rox- ithromycin 2.7%, while jatifloxacin, sparfloxacin, azithromycin, and josamycin...