期刊论文

中文

实用预防医学

1006-3110

2006

13

4

818-820

10.3969/j.issn.1006-3110.2006.04.005

湖南省卫生厅科研基金资助（B2005085）；

本校为第一机构

目的 观察不同剂量的乙醇、甲醇对小鼠神经功能的影响。方法 用急性灌胃的方法染毒小鼠，实验分三组，即甲醇染毒组、乙醇染毒组、甲醇与乙醇组，采用爬杆实验装置测定小鼠神经功能，用秒表测定小鼠染毒前后的爬杆时间，分析各组间及组内处理爬杆时间的差异。结果 小鼠爬杆时间随乙醇、甲醇染毒的剂量增大而减少，呈明显的剂量一效应关系，经统计分析显示，差异有显著性。结论 甲醇与乙醇影响小鼠的爬杆时间，具有神经毒性。

Objective To observe the mice nerve function impairment induced by different doses of alcohols. Methods Experimental mice were given alcohols, methanol and/or ethanol at various dosages to induce nerve function impairment and observed by the climbing- pole experiment method. Results The climbing - stick time of mice was decreasing alter feeding with alcohols. The climbing- stick time of mice dropped dependently with the doses of alcohols, ethanol and/or methanol, and showed a significant dose - effect relationship. Conclusion The result su...