期刊论文

中文

实用预防医学

1006-3110

2004

11

6

1122-1123

10.3969/j.issn.1006-3110.2004.06.016

本校为第一机构

目的观察SD(Spraque dawley)大鼠吸入烹调油烟(cooking oil fumes,COF)后肺组织病理形态改变,研究COF的慢性毒性及其致癌作用.方法以SD大鼠作为实验对象,通过动式吸入染毒12.5个月,共染毒191次,每次30 min,低、中、高剂量组大鼠分别吸入浓度为(6.88±0.31)、(15.06±0.35)、(35.33±1.69)mg/m3油烟颗粒,空白对照组吸人清洁空气,复制COF慢性动物实验模型.用HE染色法观察大鼠肺组织病理形态改变.结果HE染色光镜观察,261只大鼠,镜检分别表现为正常支气管上皮组织、慢性支气管炎、间质性肺炎、非典型增生、肺哝肿和在实验组中有1例原位癌及17例肺腺癌等不同病理改变;COF诱发SD大鼠肺癌总发生率为9.4...

Objective TO study the pathological changes of lung tissues of rats exposed to COF. Methods SD rats were used to make the chronic toxicity model.Experiment groups had been exposed to COF of three kinds of different concentration(6.88±0.31)、(15.06±0.35)、(35.33±1.69)mg/m3 for 191 times in 12.5 months, 30 minutes each time. Control group had inhaled clean air. HE staining was used to observe the pathological changes of SD rats. Results HE stainig pathological result showed that there were normal bronchial epithelium、 atypical hyperplasia amo...