期刊论文

中文

实用预防医学

1006-3110

2001

8

1

21-22

10.3969/j.issn.1006-3110.2001.01.010

湖南省教育厅科研项目

本校为第一机构

目的观察甲壳低聚糖对抗生素脱污染小鼠肠道菌群的影响,为进一步开发壳聚糖提供理论依据.方法用盐酸林可霉素复制肠道脱污染小鼠动物模型,将模型小鼠随机分为治疗组和对照组,治疗组灌服甲壳低聚糖600mg@kg-1@d-1,对照组灌服等体积蒸馏水.7天后分析肠道菌群.结果模型小鼠治疗组肠道菌群基本恢复正常,与对照组相比差异具有显著性意义(P＜0.05).结论甲壳低聚糖对小鼠肠道菌群失调具有一定的调整作用.

Objective To investigate the effect of chitooligosaccharides on intestinal flora in mice which were decontaminated b y antibiotics and to provide a theoretical support for developing chitosan. Methods The animal model of bacteriun free mice i n intestine was replicated with Lincomycin hydrochloride, then mice were divided randomly into a treated group and a control group. The treated group was admini stered(ig) chitooligosaccharides at a does of 600 mg/kg·d for seven days, the c ontrol group was received the equal volume of distilled water for...