期刊论文

The Study of Inducing Mycoplasma Hominis Resistance and Cross-resistance With Antibiotic Subinhibitory Concentration of Quinoloes.

中文

实用预防医学

1006-3110

2000

7

1

12-14

10.3969/j.issn.1006-3110.2000.01.005

:湖南省科技厅科研项目

本校为第一机构

[目的 ]　了解Mh对喹喏酮类药物的耐药状况 ,指导合理使用抗生素。 [方法 ]　将标准株与敏感株分别进行诱导耐药与交叉耐药试验。 [结果 ]　氧氟沙星、左旋氧氟沙星、盐酸环丙沙星诱导的Mh对氧氟沙星、左旋氧氟沙星、盐酸环丙沙星、司帕沙星均产生耐药。司帕沙星诱导耐药的Mh对氧氟沙星、盐酸环丙沙星、左旋氧氟沙星无明显交叉耐药。 [结论 ]　Mh长期接触低浓度喹诺酮类药物会诱导产生耐药性 ,而且大多数呈现稳定耐药与交叉耐药。

Objective] To acquire the information about the present resistance characteristics in Mycoplasma hominis(Mh), especially in Quinolones, and to instruct reasonable application of antibiotics clinically. [Methods] A total of 5 isolates Mh from clinical specimens and 1 standard strain were induced resistance and cross-resistance. [Results] OFX-resistant Mh showed cross-resistance to LFX and CFX and SFX. Similarly, LFX-resistance Mh cross-resistance to OFX and CFX and SFX, CFX-resistance Mh cross-resistance to OFX and LFX and SFX. However, SFX-resistance Mh did not appear cross-resistance to OFX a...