Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism

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成果类型：

期刊论文

作者：

Zhang, Caiping;Xiang, Debiao;Zhao, Qian;Jiang, Susu;Wang, Chuyao;...

通讯作者：

Liao, DF;Liu, ZG

作者机构：

[Wang, Chuyao; Yuan, Yulin; Zhao, Qian; Jiang, Susu; Yang, Huixian; Long, Shiyin; Zhang, Caiping] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

[Wen, Hongyan; Liao, DF; Liao, Duanfang; Xiang, Debiao; Huang, Ying; Tuo, Qinhui; Zeng, Yaling] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.

[Huang, Zhixin; Liu, ZG; Liu, Xuanyou; Liu, Zhenguo; Hao, Hong; Zhang, Caiping] Univ Missouri, Ctr Precis Med, Dept Med,Sch Med, Div Cardiovasc Med, Columbia, MO USA.

[Xiang, Debiao] Third Hosp Changsha, Dept Pharm, Changsha, Peoples R China.

[Liu, ZG; Liu, Zhenguo] Univ Missouri, Sch Med, Dept Med, Div Cardiovasc Med, 1 Hosp Dr, CE344, Columbia, MO 65211 USA.

通讯机构：

[Liao, DF ] H

[Liu, ZG ] U

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.

Univ Missouri, Ctr Precis Med, Dept Med,Sch Med, Div Cardiovasc Med, Columbia, MO USA.

Univ Missouri, Sch Med, Dept Med, Div Cardiovasc Med, 1 Hosp Dr, CE344, Columbia, MO 65211 USA.

语种：

英文

关键词：

Curcumin nicotinate;Hyperlipidemia;Low-density lipoprotein receptor;PCSK9;Rosuvastatin

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2022

卷：

931

页码：

175195

DOI：

10.1016/j.ejphar.2022.175195

基金类别：

This work was supported by the National Nature Science Fund of China (No. 81673722 , No. 81670268 , and No. 81773736 ); the Nature Science Fund of Hunan province (No. 2022JJ3051 ); Key Projects of Department of Education (No. 20A379 ) of Hunan province and the fund of Science and Technology Department in Changsha, Hunan Province (No. kql801109 , No. 2022SK2011 ), and the Construct Program of the Pharmaceutical Science Key Discipline in Hunan Province.

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Curcumin nicotinate (Curtn) is a synthesized ester derivative of curcumin and niacin. Our previous study has shown that Curtn lowers serum low-density lipoprotein cholesterol (LDL-C) levels in apoE(-/-) mice and promotes LDL-C uptake into HepG2 cells in vitro. The present study was to test the hypothesis that Curtn decreases serum LDL-C levels through decreased expression of pro-protein convertase subtilisin/kexin type 9 (PCSK9) and subsequent increase in LDL receptor expression. Male Wistar rats on high-fat diet (HFD) were treated with Curtn or rosuvastatin. Curtn or rosuvastatin treatment si...

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Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism

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