Diallyl disulfide down-regulates calreticulin and promotes C/EBP alpha expression in differentiation of human leukaemia cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Jing;Mu, Hongxiang;Yu, Jia;Li, Linwei;Yan, Hongxia;...

通讯作者：

Yi, Lan

作者机构：

[Yang, Xiaoyan; Yi, Lan; Tan, Hui; Mu, Hongxiang; Sun, Jing; Li, Guoqing; Yang, Nanyang; Yu, Jia] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

[Yang, Xiaoyan; Yi, Lan; Tan, Hui; Mu, Hongxiang; Sun, Jing; Li, Guoqing; Yang, Nanyang; Yu, Jia] Univ South China, Biol Res Inst, Coll Pharm & Biol Sci, Hengyang, Hunan, Peoples R China.

[Yan, Hongxia; Li, Linwei] Univ South China, Affiliated Hosp 2, Dept Lab, Hengyang, Hunan, Peoples R China.

通讯机构：

[Yi, Lan] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

Univ South China, Biol Res Inst, Coll Pharm & Biol Sci, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

C/EBPα;calreticulin;diallyl disulphide;differentiation;human leukaemia cells

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2019

卷：

期：

页码：

194-204

DOI：

10.1111/jcmm.13904

基金类别：

National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81400117, 81602249]; University of South China [2014XQD46]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ4042, 2018JJ3454]; Hunan Provincial Postgraduate Students Scientific Research Innovation Project [CX2016B473]; Science and Technology Development Project [2017KJ286]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Diallyl disulfide (DADS), the main active component of the cancer fighting allyl sulfides found in garlic, has shown potential as a therapeutic agent in various cancers. Previous studies showed DADS induction of HL‐60 cell differentiation involves down‐regulation of calreticulin (CRT). Here, we investigated the mechanism of DADS‐induced differentiation of human leukaemia cells and the potential involvement of CRT and CCAAT enhancer binding protein‐α (C/EBPα). We explored the expression of CRT and C/EBPα in clinical samples (20 healthy pe...

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Diallyl disulfide down-regulates calreticulin and promotes C/EBP alpha expression in differentiation of human leukaemia cells

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