Diallyl disulfide down-regulates calreticulin and promotes C/EBPα expression in differentiation of human leukaemia cells

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成果类型：

期刊论文

作者：

Sun, Jing;Mu, Hongxiang;Yu, Jia;Li, Linwei;Yan, Hongxia;...

通讯作者：

Yi, Lan

作者机构：

[Yang, Xiaoyan; Yi, Lan; Tan, Hui; Mu, Hongxiang; Sun, Jing; Li, Guoqing; Yang, Nanyang; Yu, Jia] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

[Yang, Xiaoyan; Yi, Lan; Tan, Hui; Mu, Hongxiang; Sun, Jing; Li, Guoqing; Yang, Nanyang; Yu, Jia] Univ South China, Biol Res Inst, Coll Pharm & Biol Sci, Hengyang, Hunan, Peoples R China.

[Yan, Hongxia; Li, Linwei] Univ South China, Affiliated Hosp 2, Dept Lab, Hengyang, Hunan, Peoples R China.

通讯机构：

[Yi, Lan] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

Univ South China, Biol Res Inst, Coll Pharm & Biol Sci, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

calreticulin;CCAAT enhancer binding protein alpha;diallyl disulfide;messenger RNA;reactive oxygen metabolite;small interfering RNA;allyl compound;antineoplastic agent;calreticulin;calreticulin, human;CCAAT enhancer binding protein;CEBPA protein, human;diallyl disulfide;disulfide;adolescent;adult;aged;animal experiment;animal model;apoptosis;Article;bone marrow biopsy;cell differentiation;cell proliferation;child;controlled study;down regulation;female;flow cytometry;gene expression;genetic transfection;HL-60 cell line;human;human cell;immunofluorescence test;immunoprecipitation;leukemia cell;male;mouse;nonhuman;normal human;polymerase chain reaction;priority journal;protein expression;real time polymerase chain reaction;reverse transcription polymerase chain reaction;signal transduction;tumor growth;tumor volume;upregulation;Western blotting;3' untranslated region;acute myeloid leukemia;animal;blood;cell differentiation;down regulation;drug effect;drug screening;genetics;metabolism;middle aged;pathology;SCID mouse;very elderly;young adult;3' Untranslated Regions;Adolescent;Adult;Aged;Aged, 80 and over;Allyl Compounds;Animals;Antineoplastic Agents, Phytogenic;Calreticulin;CCAAT-Enhancer-Binding Proteins;Cell Differentiation;Disulfides;Down-Regulation;Female;HL-60 Cells;Humans;Leukemia, Myeloid, Acute;Male;Mice, SCID;Middle Aged;Xenograft Model Antitumor Assays;Young Adult

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2019

卷：

期：

页码：

194-204

DOI：

10.1111/jcmm.13904

基金类别：

The present study was sponsored by the National Natural Scientific Foundation of China (81400117) (Dr Lan Yi) (81602249) (Dr Nanyang Yang) had a role in data collection and analysis. The Hunan Provincial Natural Science Foundation of China (2015JJ4042) (Dr Lan Yi) (2018JJ3454) (Dr Jia Yu) had a role in study design and decision to publish. Hunan Provincial Postgraduate Students Scientific Research Innovation Project (CX2016B473) (Miss Jing Sun) had a role in data collection and analysis. The returned personnel Initial Funding of University of South China (2014XQD46) (Dr Lan Yi) had a role in preparation of the manuscript. The Science and Technology Development Project of Hengyang (no. 2017KJ286) had a role in publication fee preparation. National Natural Scientific Foundation of China, Grant/Award Number: 81400117, 81602249; Returned Personnel Initial Funding of University of South China, Grant/Award Number: 2014XQD46; Hunan Provincial Natural Science Foundation of China, Grant/Award Number: 2015JJ4042, 2018JJ3454; Hunan Provincial Postgraduate Students Scientific Research Innovation Project, Grant/Award Number: CX2016B473; The Science and Technology Development Project, Grant/Award Number: 2017KJ286

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Diallyl disulfide (DADS), the main active component of the cancer fighting allyl sulfides found in garlic, has shown potential as a therapeutic agent in various cancers. Previous studies showed DADS induction of HL-60 cell differentiation involves down-regulation of calreticulin (CRT). Here, we investigated the mechanism of DADS-induced differentiation of human leukaemia cells and the potential involvement of CRT and CCAAT enhancer binding protein-α (C/EBPα). We explored the expression of CRT and C/EBPα in clinical samples (20 healthy people...

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Diallyl disulfide down-regulates calreticulin and promotes C/EBPα expression in differentiation of human leukaemia cells

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