UV Irradiation-Induced Cyclic-to-Linear Topological Changes of a Light/pH Dual-Sensitive Cyclic Copolymer for Enhanced Drug Delivery

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Hongbing;Guo, Zheng;Ma, Wei;Li, Shuang;Wang, Dun;...

通讯作者：

Yu, Cui-Yun;Wei, H

作者机构：

[Liu, Hongbing; Wei, Hua; Guo, Zheng; Ma, Wei; Liu, Ying; Yu, Cui-Yun; Wei, H; Zheng, Zhi; Li, Shuang; Wang, Dun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

[Liu, Hongbing; Wei, Hua; Guo, Zheng; Ma, Wei; Liu, Ying; Yu, Cui-Yun; Wei, H; Zheng, Zhi; Li, Shuang; Wang, Dun] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Yu, CY; Wei, H ] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

ACS Macro Letters

ISSN：

2161-1653

年：

2023

卷：

期：

页码：

1025-1030

DOI：

10.1021/acsmacrolett.3c00265

基金类别：

Thousand Young Talent Program; Foundation of Hunan Provincial Natural Science Foundation of China [2022JJ40381]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Cyclic polymers with cleavable backbones triggered by either external or internal stimuli can realize simultaneous extracellular stability and intracellular destabilization of cyclic polymer-based nanocarriers but remain seldom reported. To this end, we prepared herein cyclic-ONB-P(OEGMA-st-DMAEMA) (c-ONB-P(OEGMA-st-DMAEMA)) with a light-cleavable junction in the polymer backbone based on oligo (ethylene glycol) monomethyl ether methacrylate (OEGMA) and N,N-dimethylaminoethyl methacrylate (DMAEMA) using a light-cleavable atom transfer radical p...

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UV Irradiation-Induced Cyclic-to-Linear Topological Changes of a Light/pH Dual-Sensitive Cyclic Copolymer for Enhanced Drug Delivery

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