Chronic stress induces platinum and Niraparib resistance in mouse models of ovarian cancer

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成果类型：

期刊论文

作者：

Liu, Mu;Zhou, Xiaofang;Sun, Lijuan;Tan, Shanmei;Liu, Tingting;...

通讯作者：

Tang, J

作者机构：

[Zhou, Xiaofang; Tang, Jie; Liu, Mu] Cent South Univ, Hunan Canc Hosp, Xiangya Sch Med, Dept Gynecol Oncol,Affiliated Canc Hosp, Changsha 410013, Peoples R China.

[Sun, Lijuan] Shaoyang Cent Hosp, Dept Gynecol & Obstet, Shaoyang 422000, Peoples R China.

[Tan, Shanmei] Univ South China, Peoples Hosp Huaihua 1, Dept Gynecol & Obstet, Affiliated Huaihua Hosp, Huaihua 418000, Peoples R China.

[Liu, Tingting] First Peoples Hosp Changde, Dept Gynecol & Obstet, Changde 415000, Peoples R China.

[Xiao, Wangli] First Peoples Hosp Yueyang, Dept Gynecol & Obstet, Yueyang 414000, Peoples R China.

通讯机构：

[Tang, J ] C

Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Dept Gynecol Oncol,Hunan Gynecol Canc Res Ctr,Aff, 283 Tongzipo Rd, Changsha 410013, Peoples R China.

语种：

英文

关键词：

*Chronic stress;*Drug resistance;*Gene expression;*Mouse models;*Ovarian cancer;*Transcriptomics

期刊：

Experimental Cell Research

ISSN：

0014-4827

年：

2022

卷：

410

期：

页码：

112935

DOI：

10.1016/j.yexcr.2021.112935

基金类别：

This work was supported by Grants from the Guidance Project of Clinical Medical Technology Innovation of Hunan Province ( 2020SK51101 ); General Project of Natural Science Foundation of Hunan Province (No. 2020JJ4051 ); Promotion Project of Health Suitability Program in Health Department of Hunan Province ( WZ2020-15 ); National Cancer Center climbing fund (NO. NCC2018B61 ); Hunan Cancer Hospital Climb Plan ( ZX2020004-4 ); Capacity building project of central subsidized medical and health institutions ( 20211127–100 ); Key Specialty Construction Project in Hunan Province , China (No. 20210826-1004 ); General Project in Health Department of Hunan Province , China (No. 202205015388 ).

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摘要：

Resistance to platinum and PARP inhibitors represents a major barrier to the long-term survival of ovarian cancer patients. We aim to explore the potential role of chronic stress in drug resistance in ovarian cancer. Leveraging four ovarian cancer with chronic stress (OCCS) mouse models, we explore the therapeutic efficacy of platinum, Niraparib, and Docetaxel treatment in vivo, and compare the efficacy of these anti-tumor drugs in vitro using cell viability assays. Comparing the transcriptional characteristics in RNA-Seq of OCCS mice with publ...

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Chronic stress induces platinum and Niraparib resistance in mouse models of ovarian cancer

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