Exosome-packaged mir-1246 contributes to bystander dna damage by targeting lig4

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成果类型：

期刊论文

作者：

Mo, Li-Jun;Song, Man;Huang, Qiao-Hua;Guan, Hua;Liu, Xiao-Dan;...

通讯作者：

Zhou, Ping-Kun;Huang, Rui-Xue

作者机构：

[Mo, Li-Jun; Huang, Bo; Huang, Qiao-Hua] Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hlth, Hengyang 421001, Hunan, Peoples R China.

[Mo, Li-Jun; Guan, Hua; Liu, Xiao-Dan; Zhou, Ping-Kun; Song, Man; Xie, Da-Fei] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Huang, Rui-Xue] Cent S Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

[Zhou, Ping-Kun] Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp, Guangzhou 511436, Guangdong, Peoples R China.

通讯机构：

[Zhou, Ping-Kun] B

[Huang, Rui-Xue] C

[Zhou, Ping-Kun] G

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Cent S Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

语种：

英文

期刊：

British Journal of Cancer

ISSN：

0007-0920

年：

2018

卷：

119

期：

页码：

492-502

DOI：

10.1038/s41416-018-0192-9

基金类别：

National Key Basic Research Program (973 Program) of MOST, China [2015CB910601]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31370843, 31500681]; Natural Science foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ2115]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: An increasing number of studies have recently reported that microRNAs packaged in exosomes contribute to multiple biological processes such as cancer progression; however, little is known about their role in the development of radiation-induced bystander effects. METHODS: The exosomes were isolated from the culture medium of BEP2D cells with or without γ-ray irradiation by ultracentrifugation. To monitor DNA damage and repair efficiency, the DNA double-strand break biomarker 53BP1 foci, comet, micronuclei, expression of DNA repair ...

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Exosome-packaged mir-1246 contributes to bystander dna damage by targeting lig4

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