期刊论文

Liu, Lu Shan;Tang, Zhi Han

英文

CURRENT MEDICINAL CHEMISTRY

0929-8673

2021

28

36

7446-7460

10.2174/0929867328666210531150302

Not applicable. FUNDING This work has been supported by the National Natural Science Foundation of China (81770454 to ZH.Tang), the Key Project of the Education Department of Hunan Province (18A241 to LS. Liu), International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (2018WK4031), the first-class discipline in Hunan Province, Scientific Research Fund of Hunan Provincial Education Department (20C1612), Hunan Provincial Innovation Foundation for Postgraduate (CX20190747) and Undergraduate Innovative Experiment Project (2018XJXZ366, 2018XJXZ369, S201910555135).

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Proprotein convertase subtilisin/Kexin type 9 (PCSK9) is a secretory serine protease that plays multiple biological functions in the regulation of physiological and pathological processes. PCSK9 inhibitors decrease the circulating LDL-cholesterol level with well-known preventive and therapeutic effects on atherosclerosis (AS). Still, increasing evidence shows that the direct impact of PCSK9 on the vascular wall also plays an important role in atherosclerotic progression. Compared with other vascular cells, a large proportion of PCSK9 is origina...