期刊论文

Zheng, Xing

英文

Pharmaceutical Chemistry Journal

0091-150X

2020

54

9

924-931

10.1007/s11094-020-02298-5

This research was supported by the National Natural Science Foundation of China (No. 81273537); the Key Project of Hunan Province Science and Technology Department (No.2016DK2001), the Key Project of Hengyang Science and Technology Department (No. 2017KJ166), the Key Disciplines of Hunan Province and Zhengxiang Scholar Program of the University of South China, Joint Funds of Hunan Province and Hengyang City (2017JJ4050), Hunan Provincial Natural Science Foundation of China(2018JJ3456), and the Project of Education Department of Hunan Province (17C1398).

本校为第一且通讯机构

Genistein is a phytoestrogen compound which possesses multiple biological activities such as anti-cancer, while its application is limited by poor pharmacokinetic properties. Structural modification is an effective approach to get genistein derivatives with better activities and approved pharmacokinetic properties. Based on previous research work, we synthesized two series of genistein derivatives bearing halogen substituents, and evaluated their inhibitory effects on the cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-435. Among these derivatives, compound XI displayed the best inhibitory act...