期刊论文

Zheng, Xing

英文

Pharmaceutical Chemistry Journal

0091-150X

2020

54

9

924-931

10.1007/s11094-020-02298-5

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273537]; Key Project of Hunan Province Science and Technology Department [2016DK2001]; Key Project of Hengyang Science and Technology Department [2017KJ166]; Key Disciplines of Hunan Province; Zhengxiang Scholar Program of the University of South China; Fund of Hunan Province [2017JJ4050]; Fund of Hengyang City [2017JJ4050]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3456]; Project of Education Department of Hunan Province [17C1398]

本校为第一且通讯机构

Genistein is a phytoestrogen compound which possesses multiple biological activities such as anti-cancer, while its application is limited by poor pharmacokinetic properties. Structural modification is an effective approach to get genistein derivatives with better activities and approved pharmacokinetic properties. Based on previous research work, we synthesized two series of genistein derivatives bearing halogen substituents, and evaluated their inhibitory effects on the cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-435. Among these derivatives, compound XI displayed the best inhibitory act...