Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization

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成果类型：

期刊论文

作者：

Duan, Meng;Chen, Hainan;Yin, Linjie;Zhu, Xiao;Novak, Petr;...

通讯作者：

Yin, K;Zhao, GJ

作者机构：

[Yin, Kai; Duan, Meng] Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Dept Cardiol, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China.

[Yin, Kai; Duan, Meng; Novak, Petr; Lv, Yuncheng; Zhu, Xiao] Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin, Guangxi, Peoples R China.

[Chen, Hainan; Yin, Kai; Duan, Meng; Yin, Linjie] Univ South China, Hengyang Med Sch, Res Lab Translat Med, Hengyang, Peoples R China.

[Chen, Hainan] Sun Yat Sen Univ, Ctr Stem Cell Biol & Tissue Engn, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou, Peoples R China.

[Zhao, Guojun; Zhao, GJ] Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Guangdong, Peoples R China.

通讯机构：

[Zhao, GJ ; Yin, K ] G

Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Dept Cardiol, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China.

Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin, Guangxi, Peoples R China.

Univ South China, Hengyang Med Sch, Res Lab Translat Med, Hengyang, Peoples R China.

Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Guangdong, Peoples R China.

语种：

英文

关键词：

AIBP;Mitophagy;Atherosclerosis;Macrophage polarization

期刊：

Cell Communication and Signaling

ISSN：

1478-811X

年：

2022

卷：

期：

页码：

1-18

DOI：

10.1186/s12964-022-00858-8

基金类别：

This study was supported by the National Natural Sciences Foundation of China (Grant Numbers 81970390 and 82060065), and the Key Project of the Natural Science Foundation of Guangxi Zhuang Autonomous Region, China (Grant Number 2020JJD140029). The Grant for the Guangxi Medical High-level Key Talents Training (139 plan).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Apolipoprotein A-I binding protein (AIBP), a secreted protein, has been shown to play a pivotal role in the development of atherosclerosis. The function of intracellular AIBP, however, is not yet well characterized. Here, we found that AIBP is abundantly expressed within human and mouse atherosclerotic lesions and exhibits a distinct localization in the inner membrane of mitochondria in macrophages. Bone marrow-specific AIBP deficiency promotes the progression of atherosclerosis and increases macrophage infiltration and inflammation in low-dens...

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Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization

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