Evaluation of urinary metal concentrations and sperm DNA damage in infertile men from an infertility clinic

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成果类型：

期刊论文

作者：

Zhou, Yan*;Fu, Xiao-Ming;He, Dong-Liang;Zou, Xue-Min;Wu, Cheng-Qiu;...

通讯作者：

Zhou, Yan

作者机构：

[Zhou, Yan; Guo, Wei-Zhen; Zou, Xue-Min] Changsha Med Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.

[Fu, Xiao-Ming] Hunan Normal Univ, Xiangnan Affiliated Hosp, Hosp Peoples Liberat Army 169, Hengyang, Hunan, Peoples R China.

[Wu, Cheng-Qiu; He, Dong-Liang] Univ South China, Sch Publ Hlth, Dept Prevent Med, Hengyang, Hunan, Peoples R China.

[He, Dong-Liang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Wuhan, Hubei, Peoples R China.

[Feng, Wei] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China.

通讯机构：

[Zhou, Yan] C

Changsha Med Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Comet assay;Male infertility;Male reproductive health;Metals;Sperm DNA damage

期刊：

Environmental Toxicology and Pharmacology

ISSN：

1382-6689

年：

2016

卷：

页码：

68-73

DOI：

10.1016/j.etap.2016.05.020

基金类别：

We sincerely thank all the study subjects in this study for providing their urine and semen samples. This work was supported by the Fund Project of Hunan Province Education Office (Project Number: 2014C0996) and the Fund Project of Hunan Provincial Department of Health (Project Number: B2013-036).

机构署名：

本校为其他机构

院系归属：

医学院

公共卫生学院

摘要：

This study aimed to examine associations between urinary metal concentrations and sperm DNA damage. Thirteen metals [arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), manganese (Mn), molybdenum (Mo), mercury (Hg), nickel (Ni), selenium (Se), and zinc (Zn)] were detected in urine samples of 207 infertile men from an infertility clinic using inductively coupled plasma mass spectrometry, and also, sperm DNA damage (tail length, percent DNA tail, and tail distributed moment) were assessed using neutral comet assay. We found that urinary Hg and Ni were assoc...

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Evaluation of urinary metal concentrations and sperm DNA damage in infertile men from an infertility clinic

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