Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

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成果类型：

期刊论文

作者：

Chen, Hainan;Liu, Yijian;Gui, Qingjun;Zhu, Xiao;Zeng, Lin;...

通讯作者：

He, Jin;Yin, Kai

作者机构：

[Gao, Ling; Chen, Hainan; Yin, Kai; Feng, Juling; Jackson, Ampadu O.; Li, Yi; Gui, Qingjun; Qing, Jina; Zhu, Xiao] Univ South China, Med Sch, Res Lab Clin & Translat Med, Hengyang 421001, Peoples R China.

[Chen, Hainan; Yin, Kai; Zhu, Xiao] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Liu, Yijian] Third Hosp Changsha, Changsha 410000, Hunan, Peoples R China.

[Zeng, Lin] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Peoples R China.

[Meng, Jun; He, Jin] Univ South China, Affiliated Hosp 1, Funct Dept, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[He, Jin; Yin, Kai] U

Univ South China, Affiliated Hosp 1, Funct Dept, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Res Lab Clin & Translat Med, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

*Acute myocardial infarction;*EndMT;*Ghrelin;*Myocardial fibrosis;*Smad7;*TGF-beta1

期刊：

Peptides

ISSN：

0196-9781

年：

2019

卷：

111

期：

页码：

118-126

DOI：

10.1016/j.peptides.2018.09.001

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100213, 81470569]; Innovation Foundation for Postgraduate of Hunan Province [CX2017B550, CX2016B490]; Scientific Research Foundation for Doctor in University of South China [2015XQD49]; Scientific Research Foundation for the Returned Overseas Chinese Scholars in University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2015XQD55]; Natural Science Foundation of Hunan Proince, China [2018JJ2341, 2016JJ2109]; National college students innovation and entrepreneurship fund [201710555015, 201710555010]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending (LAD). Ghrelin or saline was intraperitoneally injected two times per day for 8 weeks after ligation. The weight of heart (mg) and the weight ratio o...

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Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

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