Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

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成果类型：

期刊论文

作者：

Chen, Hainan;Liu, Yijian;Gui, Qingjun;Zhu, Xiao;Zeng, Lin;...

通讯作者：

He, Jin;Yin, Kai

作者机构：

[Gao, Ling; Chen, Hainan; Yin, Kai; Feng, Juling; Jackson, Ampadu O.; Li, Yi; Gui, Qingjun; Qing, Jina; Zhu, Xiao] Univ South China, Med Sch, Res Lab Clin & Translat Med, Hengyang 421001, Peoples R China.

[Chen, Hainan; Yin, Kai; Zhu, Xiao] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Liu, Yijian] Third Hosp Changsha, Changsha 410000, Hunan, Peoples R China.

[Zeng, Lin] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Peoples R China.

[Meng, Jun; He, Jin] Univ South China, Affiliated Hosp 1, Funct Dept, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[He, Jin; Yin, Kai] U

Univ South China, Affiliated Hosp 1, Funct Dept, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Res Lab Clin & Translat Med, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

collagen;ghrelin;ghrelin receptor;hydroxymethylglutaryl coenzyme A reductase kinase;Smad2 protein;Smad3 protein;Smad7 protein;sodium chloride;transforming growth factor beta1;ghrelin;ghrelin receptor;acute heart infarction;animal experiment;Article;attenuation;body weight;CAEC cell line;controlled study;coronary artery ligation;drug blood level;drug mechanism;epithelial mesenchymal transition;heart muscle fibrosis;heart weight;human;human cell;human cell culture;in vitro study;in vivo study;left anterior descending coronary artery;male;nonhuman;priority journal;protein expression;protein phosphorylation;rat;serum;signal transduction;animal;blood;cardiomyopathy;cell culture;echocardiography;enzyme linked immunosorbent assay;epithelial mesenchymal transition;fibrosis;fluorescent antibody technique;heart infarction;metabolism;real time polymerase chain reaction;Sprague Dawley rat;Western blotting;Animals;Blotting, Western;Cardiomyopathies;Cells, Cultured;Echocardiography;Enzyme-Linked Immunosorbent Assay;Epithelial-Mesenchymal Transition;Fibrosis;Fluorescent Antibody Technique;Ghrelin;Humans;Male;Myocardial Infarction;Rats;Rats, Sprague-Dawley;Real-Time Polymerase Chain Reaction;Receptors, Ghrelin

期刊：

Peptides

ISSN：

0196-9781

年：

2019

卷：

111

期：

页码：

118-126

DOI：

10.1016/j.peptides.2018.09.001

基金类别：

This research was supported by the National Natural Sciences Foundation of China [grant numbers 81100213, 81470569]; The Innovation Foundation for Postgraduate of Hunan Province [grant number CX2017B550, CX2016B490]; Scientific Research Foundation for Doctor in University of South China [grant number 2015XQD49]; and the Scientific Research Foundation for the Returned Overseas Chinese Scholars in University of South China [grant number 2015XQD55]; Natural Science Foundation of Hunan Proince, China [grant number 2018JJ2341, 2016JJ2109]; National college students innovation and entrepreneurship fund [grant number 201710555015, 201710555010]. This research was supported by the National Natural Sciences Foundation of China [grant numbers 81100213 , 81470569 ]; The Innovation Foundation for Postgraduate of Hunan Province [grant number CX2017B550 , CX2016B490 ]; Scientific Research Foundation for Doctor in University of South China [grant number 2015XQD49 ]; and the Scientific Research Foundation for the Returned Overseas Chinese Scholars in University of South China [grant number 2015XQD55 ]; Natural Science Foundation of Hunan Proince, China [grant number 2018JJ2341 , 2016JJ2109 ]; National college students innovation and entrepreneurship fund [grant number 201710555015 , 201710555010 ].

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending (LAD). Ghrelin or saline was intraperitoneally injected two times per day for 8 weeks after ligation. The weight of heart (mg) and the weight ratio o...

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Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

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