期刊论文

Wang, T;Mao, Longfei;Li, SQ

英文

Journal of Molecular Structure

0022-2860

2024

1298

137042

10.1016/j.molstruc.2023.137042

This work was supported by National Natural Science Foundation of China (NO. 82170606, 81070125, 81270213, 81670306), Basic Research Project of Key Scientific Research Projects of Universities in Henan Province (23ZX006), the Science and Technology Foundation in Guangdong Province (No. 2010B031600032, 2014A020211002), the National Natural Science Foundation of Guangdong Province (No. 2017A030313503), the Science and Technology Foundation in Guangzhou City (No. 201806020084), Shenzhen Science and Technology Program (No. JCYJ20210324115208024, JCYJ20190808101405466, JCYJ20210324115003008, JCYJ20220530144404009), Shenzhen Outbound Postdoctoral Research Grant (No.CZBSHKYJJ002).

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A series of 28 novel cabotegravir derivatives, incorporating the 1,2,3-triazole moiety, were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against four different human cancer cell lines: HuH-7 (hepatocellular), MCF-7 (breast), SKOV3 (ovarian), and HCT-116 (colon). Initial biological assessments revealed that several compounds exhibited potent anti-proliferative activity against these cancer cell lines. Notably, compounds KJ9 and KJ23 demonstrated the most pronounced effects, with IC50 values of 6.59 and 7.83 mu M in HuH-7 cells, 27.2...