-blockers inhibit the viability of breast cancer cells by regulating the ERK/COX-2 signaling pathway and the drug response is affected by ADRB2 single-nucleotide polymorphisms

首页 > 成果 > 详情

认领

导出

下载 Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xie, Wan-Ying;He, Ruo-Hui;Zhang, Jun;He, Yi-Jing;Wan, Zan;...

通讯作者：

Liu, Jie

作者机构：

[Xie, Wan-Ying; Liu, Jie; Mcleod, Howard L.; He, Ruo-Hui; Li, Zhi; Tang, Yong-Jun; Wan, Zan; He, Yi-Jing; Zhou, Cheng-Fang] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Xie, Wan-Ying; Liu, Jie; He, Ruo-Hui; Li, Zhi; Wan, Zan; He, Yi-Jing; Zhou, Cheng-Fang] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

[Liu, Jie; He, Ruo-Hui; Li, Zhi; He, Yi-Jing] Univ South China, Cooperat Innovat Ctr Mol Target New Drug Study, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Jun] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China.

[Tang, Yong-Jun] Cent S Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Liu, Jie] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

triple-negative breast cancer;-blocker;-adrenergic receptor;mitogen-activated protein kinase signaling pathway;(2)-adrenergic receptor single-nucleotide polymorphisms

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2019

卷：

期：

页码：

341-350

DOI：

10.3892/or.2018.6830

基金类别：

National Natural Science Foundation of China [81070902]; Young Scientists Fund of the National Natural Science Foundation of China [30600774]; China Postdoctoral Science Foundation [201104515, 2012M510138]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The (2)-adrenergic receptor ((2)-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Studies in vivo and in vitro have confirmed that -blockers (-AR antagonists) exert antitumor effects on various tumors. Furthermore, ADRB2 single-nucleotide polymorphisms (SNPs) have been identified to alter the expression and conformation of (2)-AR, which may alter the -blocker drug response. The aim of the present study was to investigate the effect of -blockers on triple-negative breast cancer cells and determine whether ADRB2 SN...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

-blockers inhibit the viability of breast cancer cells by regulating the ERK/COX-2 signaling pathway and the drug response is affected by ADRB2 single-nucleotide polymorphisms

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问