β-blockers inhibit the viability of breast cancer cells by regulating the ERK/COX-2 signaling pathway and the drug response is affected by ADRB2 single-nucleotide polymorphisms

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成果类型：

期刊论文

作者：

Xie, Wan-Ying;He, Ruo-Hui;Zhang, Jun;He, Yi-Jing;Wan, Zan;...

通讯作者：

Liu, Jie

作者机构：

[Xie, Wan-Ying; Liu, Jie; Mcleod, Howard L.; He, Ruo-Hui; Li, Zhi; Tang, Yong-Jun; Wan, Zan; He, Yi-Jing; Zhou, Cheng-Fang] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Xie, Wan-Ying; Liu, Jie; He, Ruo-Hui; Li, Zhi; Wan, Zan; He, Yi-Jing; Zhou, Cheng-Fang] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

[Liu, Jie; He, Ruo-Hui; Li, Zhi; He, Yi-Jing] Univ South China, Cooperat Innovat Ctr Mol Target New Drug Study, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Jun] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China.

[Tang, Yong-Jun] Cent S Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Liu, Jie] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol;beta 2 adrenergic receptor;beta adrenergic receptor blocking agent;cyclooxygenase 2;messenger RNA;metoprolol;mitogen activated protein kinase 1;mitogen activated protein kinase 3;propranolol;3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol;ADRB2 protein, human;beta 2 adrenergic receptor;beta adrenergic receptor blocking agent;cyclooxygenase 2;mitogen activated protein kinase;propanolamine derivative;propranolol;PTGS2 protein, human;ADRB2 gene;apoptosis;Article;breast cancer cell line;cell viability;controlled study;ERK COX 2 signaling pathway;G1 phase cell cycle checkpoint;human;human cell;MDA-MB-231 cell line;priority journal;protein phosphorylation;single nucleotide polymorphism;cell survival;down regulation;drug effect;drug screening;G2 phase cell cycle checkpoint;gene expression regulation;genetics;HEK293 cell line;metabolism;phosphorylation;signal transduction;triple negative breast cancer;tumor cell line;Adrenergic beta-Antagonists;Apoptosis;Cell Line, Tumor;Cell Survival;Cyclooxygenase 2;Down-Regulation;Drug Screening Assays, Antitumor;Extracellular Signal-Regulated MAP Kinases;G2 Phase Cell Cycle Checkpoints;Gene Expression Regulation, Neoplastic;HEK293 Cells;Humans;Phosphorylation;Polymorphism, Single Nucleotide;Propanolamines;Propranolol;Receptors, Adrenergic, beta-2;Signal Transduction;Triple Negative Breast Neoplasms

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2019

卷：

期：

页码：

341-350

DOI：

10.3892/or.2018.6830

基金类别：

The present study was supported by the National Natural Science Foundation of China (grant no. 81070902), the Young Scientists Fund of the National Natural Science Foundation of China (grant no. 30600774), and the China Postdoctoral Science Foundation (grant nos. 201104515 and 2012M510138).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The β 2 -adrenergic receptor (β 2 -AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Studies in vivo and in vitro have confirmed that β-blockers (β-AR antagonists) exert antitumor effects on various tumors. Furthermore, ADRB2 single-nucleotide polymorphisms (SNPs) have been identified to alter the expression and conformation of β 2 -AR, which may alter the β-blocker drug response. The aim of the present study was to investigate the effect of β-blockers on tr...

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β-blockers inhibit the viability of breast cancer cells by regulating the ERK/COX-2 signaling pathway and the drug response is affected by ADRB2 single-nucleotide polymorphisms

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