期刊论文

Zhang, Z.;Liu, F.

英文

CLINICAL AND EXPERIMENTAL MEDICINE

1591-8890

2023

23

5

1393-1404

10.1007/s10238-022-00937-7

This study was funded by the National key research and development project (NO. 2021YFE0192100), Natural Science Foundation of Hunan Province (NO.2019JJ40258, NO. 2020JJ4083, NO.2021JJ30694), Science and Technology Innovation Project of Hunan Province (NO. 2020SK51703), Innovation and Entrepreneurship Training Program for College Students in Hunan Province (NO.S202110555296), Key Projects of Hunan Provincial Education Department (NO.21A0285), Natural Science Foundation of Hunan Provincial and Municipal Co-funding (NO.2022JJ50029) , Key projects of Shaoyang Science and Technology Bureau (NO.2021GZ031)

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Calreticulin (CRT) is a multifunctional protein found within the endoplasmic reticulum (ER). In addition, CRT participates in the formation and development of tumors and promotes the proliferation and migration of tumor cells. When a malignant tumor occurs in the human body, cancer cells that die from immunogenic cell death (ICD) expose CRT on their surface, and CRT that is transferred to the cell surface represents an "eat me" signal, which promotes dendritic cells to phagocytose the tumor cells, thereby increasing the sensitivity of tumors to anticancer immunotherapy. Expression of CRT in tu...