期刊论文

Hou, Jingjing;Yu, Yongsheng;Wan, Zhong;Feng, Qian

英文

Computational and Structural Biotechnology Journal

2001-0370

2020

18

125-136

10.1016/j.csbj.2019.12.010

This work was supported by grants from the National Natural Science Foundation of China ( 81902622 and 31900963 ), the Foundation of Fujian Provincial Department of Science and Technology (China, IDs:2019J01556, 2018-ZQN-87, and 2018-2-66 ), the Foundation of Xiamen Municipal Bureau of Science and Technology (China, IDs: 3502Z20174080 and 3502Z20184038 ), the Health-Education Joint Research Project of Fujian Province (China, ID: 2019-WJ-22 ), the Shanghai Pujiang Program (China, ID: 18PJ1409400 ), the Scientific Research Foundation of Shanghai Municipal Commission of Health and Family Planning (China, ID: 20174Y0218 ). We thank Dr. Jianchun Cai and Dr. Zeyang Lin for verifying the GC pathological diagnosis. Appendix A

本校为其他机构

The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and is associated with acquired and intrinsic resistance. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a key role in adhesion, migration, and proliferation of gastric carcinoma cells, suggesting that this kinase may be a promising therapeutic target. Differentially expressed FAK in GC tissue was detected by RT-qPCR and TCGA database analysis. To investigate the biological functions of FAK,...