期刊论文

Jiang, ZS

英文

NITRIC OXIDE-BIOLOGY AND CHEMISTRY

1089-8603

2024

142

47-57

10.1016/j.niox.2023.11.005

National Natural Science Foundation of China [91839103, 81670429]; National Key Research and Development Program of China [2019YFA0801601]; Special Funding for Construction of Innovative Provinces in Hunan Province [2020SK2105]; International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province [2018WK4031]; The "Double First-Class" project for innovative Group of Basic Medicine, University of South China; National Natural Science Foundation of Hunan Province [2021JJ30021]; Scientific Research Fund of Hunan Provincial Education Department [20B501]; Postgraduate Scientific Research Innovation Project of Hunan Province [CX20230953]

本校为第一且通讯机构

BACKGROUND: Endothelial-mesenchymal transition (EndMT) induced by low shear stress plays an important role in the development of atherosclerosis. However, little is known about the correlation between hydrogen sulfide (H(2)S), a protective gaseous mediator in atherosclerosis and the process of EndMT. METHODS: We constructed a stable low-shear-stress-induced(2dyn/cm(2)) EndMT model, acombined with the pretreatment method of hydrogen sulfide slow release agent(GYY4137). The level of MEST was detected in the common carotid artery of ApoE(-/-) mice with local carotid artery ligation. The effect of...