Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus

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成果类型：

期刊论文

作者：

Chen, Si-Min;Li, Min;Xie, Juan;Li, Sha;Xiang, Shi-Shi;...

通讯作者：

Tang, Xiao-Qing;Zhang, Ping

作者机构：

[Kuang, Xin; Xiang, Shi-Shi; Tang, Xiao-Qing; Li, Sha; Chen, Si-Min] Univ South China, Affiliated Hosp 1, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Xie, Juan; Li, Min; Tang, Xiao-Qing; Chen, Zhuo; Liu, Hai-Yao; Zhang, Ping; Chen, Si-Min] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Xie, Juan; Li, Min; Chen, Zhuo; Liu, Hai-Yao; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

[Kuang, Xin; Xiang, Shi-Shi; Li, Sha] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Zhang, Ping] U

Univ South China, Affiliated Hosp 1, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Hippocampus;Hydrogen sulfide;Postoperative cognitive dysfunction;Synaptic plasticity;Warburg effect

期刊：

Toxicology and Applied Pharmacology

ISSN：

0041-008X

年：

2020

卷：

409

期：

页码：

115286

DOI：

10.1016/j.taap.2020.115286

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82001152]; Major Research Topics of the Health Commission of Hunan province [20201911]; Hunan Provincial Innovation Foundation for Postgraduate [CX20190716]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Postoperative cognitive dysfunction (POCD) is deemed to a severe surgical complication without effective treatment. Previous work has confirmed the important modulatory role of hydrogen sulfide (H2S) in cognitive function. This study was proposed to explore whether H2S relieves POCD and the possible mechanisms. We demonstrated that NaHS (a donor of H2S) reversed the inhibited endogenous H2S generation in the hippocampus of postoperative rats. NaHS attenuated the cognitive impairment of postoperative rats in the Y-maze, Novel object recognition, and Morris water maze tests. NaHS enhanced the ex...

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Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus

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