Hydrogen Sulfide Attenuates beta 2-Microglobulin-Induced Cognitive Dysfunction: Involving Recovery of Hippocampal Autophagic Flux

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Si-Min;Yi, Yi-Li;Zeng, Dan;Tang, Yi-Yun;Kang, Xuan;...

通讯作者：

Tang, Xiao-Qing;Zou, Wei

作者机构：

[Tang, Xiao-Qing; Kang, Xuan; Chen, Si-Min] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

[Zou, Wei; Zeng, Dan; Zhang, Ping; Yi, Yi-Li] Univ South China, Dept Neurol, Affiliated Nanhua Hosp, Hengyang, Peoples R China.

[Tang, Xiao-Qing; Zou, Wei; Tang, XQ; Kang, Xuan; Zhang, Ping; Tang, Yi-Yun] Univ South China, Inst Neurosci, Hengyang Med Coll, Hengyang, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Zou, Wei; Zou, W; Tang, XQ] U

Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

Univ South China, Dept Neurol, Affiliated Nanhua Hosp, Hengyang, Peoples R China.

Univ South China, Inst Neurosci, Hengyang Med Coll, Hengyang, Peoples R China.

语种：

英文

关键词：

autophagic flux;cognitive dysfunction;hippocampus;hydrogen sulfide;beta2-microglobulin

期刊：

FRONTIERS IN BEHAVIORAL NEUROSCIENCE

ISSN：

1662-5153

年：

2019

卷：

页码：

483667

DOI：

10.3389/fnbeh.2019.00244

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671057, 81771178]; Science and Health Joint Project of Natural Science Foundation of Hunan Province [2019JJ80101]; Youth Project of Natural Science Foundation of Hunan Province [2019JJ50546]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background and Aim: Accumulation of β2-microglobulin (B2M), a systemic pro-aging factor, regulates negatively cognitive function. Hydrogen sulfide (H2S), a novel gas signaling molecule, exerts protection against cognitive dysfunction. Therefore, the present work was designed to explore whether H2S attenuates cognitive dysfunction induced by B2M and the underlying mechanism. Materials and Methods: The cognitive function of rats was assessed by Y-maze, Novel object recognition (NOR), and Morris water maze (MWM) tests. The levels of autophagosome...

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Hydrogen Sulfide Attenuates beta 2-Microglobulin-Induced Cognitive Dysfunction: Involving Recovery of Hippocampal Autophagic Flux

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