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LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease

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成果类型:
期刊论文
作者:
Ouyang, Shao;Zhou, Zhi-Xiang;Liu, Hui-Ting;Ren, Zhong;Liu, Huan;...
通讯作者:
Jiang, ZS
作者机构:
[Ouyang, Shao; Jiang, Zhi-Sheng; Ren, Zhong; Jiang, ZS; Tian, Kai-Jiang; Zhou, Kun; Liu, Huan; Deng, Nian-Hua; Xie, Hai-lin; Liu, Hui-Ting; Zhou, Zhi-Xiang] Univ South China, Inst Cardiovasc Dis, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.
[Ouyang, Shao] Univ South China, Hengyang Med Sch, Clin Med Res Ctr Arteriosclerot Dis Hunan Prov, Affiliated Hosp 2,Key Lab Heart Failure Prevent &, Hunan 421001, Peoples R China.
通讯机构:
[Jiang, ZS ] U
Univ South China, Inst Cardiovasc Dis, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Long noncoding RNAs;coronary atherosclerotic heart disease;diagnosis;drug therapy;endothelial cells;smooth muscle cell.
期刊:
CURRENT MEDICINAL CHEMISTRY
ISSN:
0929-8673
年:
2024
卷:
31
期:
10
页码:
1251-1264
基金类别:
Special Funding for Construction of Innovative Provinces in Hunan Province [2020SK2105]; National Key Research and Development Program of China [2019YFA0801601]; Clinical Medical Technology Innovation Guide Project of Hunan Province [2021SK51712]; Special Funds for the Innovative Construction of Hunan Province [2020SK4010]; Special Funds for Science and Technology Plan Project of Hengyang [2019jh426001]; Research Project of the University of South China [nk2020106]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNA...

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