期刊论文

Shen, HY

英文

Heliyon

2405-8440

2023

9

12

e23079

10.1016/j.heliyon.2023.e23079

Science Fund of Hunan Provincial Education Department [20B504, 23B0395]; Natural Science Foundation of Hunan Province [2018JJ3433]; Planning Project for Science Research of Health and Family Planning Commission of Hunan Province [D202302047808]; Undergraduate Training Programs for Innovation and Entrepre-neurship of Hunan Province [D202305162258543382]; Undergraduate Training Programs for Innovation and Entrepreneurship of University of South China [2022X10555110]

本校为第一且通讯机构

Objective: To explore the mechanism of ursolic acid (UA) against acute B lymphoblastic leukaemia (B-ALL) based on network pharmacological analysis, molecular docking and experimental verification.Methods: The core targets, functional processes, and biological pathways of UA in B-ALL were predicted by network pharmacology and molecular docking. The efficacy and mechanism of UA against B-ALL were verified through in vitro experiments such as cell viability assays, CCK-8 assays, LDH assays, AO/EB staining, flow cytometry, and Western blot assays.Results: Network pharmacology analysis of the core ...