期刊论文

Effects of Total isoflavones of pueraria on bone quality in ovariectomized rats

中文

微量元素与健康研究

1005-5320

2012

29

1

1-3+7

湖南省教育厅科研基金资助项目（09C143）；

本校为其他机构

目的:观察葛根异黄酮(TIP)对去卵巢大鼠骨骼质量的影响.方法:选用健康成年SD雌性大鼠40只,随机分为5组:假手术组、模型对照组、低、中、高剂量TIP组；假手术组切除卵巢旁脂肪组织,其余各组均切除双侧卵巢,建立去卵巢大鼠动物模型.按25、50、100 mg/kg 3个剂量的TIP分别给去卵巢大鼠灌胃3个月,实验结束后处死大鼠,用相关方法检测骨骼质量变化的指标.结果:中、高剂量TIP组动物的体重与相对应时相的模型组比较均有下降(P＜0.05)；中、高剂量TIP组大鼠股骨重量、骨钙含量与模型对照组比较增加(P＜0.05)；高剂量TIP组大鼠的血清钙含量增高,血清磷、骨钙素和碱性磷酸酶含量均低于模型对照组(P＜0.05)；...

Objective： To investigate Effects of Total isoflavones of pueraria on bone quality in ovariectomized rats. Methods： Choose healthy adult female SD rats were randomly divided into five groups： sham operation group, model control group and Total isoflavones pueraria groups of low, medium,high - dose ; Sham group removal of Ovarian side adipose tissue , the ovariectomized were established rat model of other groups.. Press 25,50,100 mg / kg three doses of Total isoflavones of pueraria, give of ovariectomized rats were fed to three month; the exp...