期刊论文

中文

微量元素与健康研究

1005-5320

2009

26

3

4-5+9

本校为第一机构

目的:观察褪黑素对高糖高脂饲养大鼠胰岛素敏感性的影响.方法:将18只雄性SD大鼠(150～200g)随机分为正常组(CD组)与高糖高脂组(HFSD组),分别饲以正常饲料与高糖高脂饲料(53%基础饲料含蔗糖37%和猪油10%)喂养6个月后,给药治疗2个月;治疗期间,给褪黑素组(Mel组)每天腹腔注射药物褪黑素(Melatonin,Mel,4 mg/kg),对照组腹腔注射生理盐水.测定空腹血糖、胰岛素、甘油三酯(TG)、游离脂肪酸(FFA)、高密度脂蛋白胆固醇(HDL-C)水平,做口服葡萄糖耐量实验(OGTT)和胰岛素敏感性实验.结果:高糖高脂饮食可诱导SD大鼠产生胰岛素抵抗,引起SD大鼠空腹血糖、血清胰岛素、TG、FFA水平升高;胰岛素敏感性、HDL-C水平...

Objective:To investigate the effects of melatonin(Mel) on insulin sensitivity in SD rats fed by high-sucrose/ high-fat diet(HFSD).Methods:18 male Sprague Dawley rats weighing 150～200 g are randomized assigned to two dietary groups,the normal control(CD) diet group,fed standard chow;the high sucrose and high fat diet group(HFSD),fed 53% normal diet supplemented with 10% lard and 37% sucrose.All rats were fed for 6 months and treated for 2 months.During ...