The experiment was supported by the National Natural Science Foundation of China (Grant numbers 81471576 , 82002182 ).
机构署名:
本校为第一机构
院系归属:
医学院
药学与生物科学学院
摘要:
Background: Neurosyphilis is a serious complication caused by the invasion of the central nervous system by Treponema pallidum subsp. pallidum (T. pallidum). However, the molecular mechanism by which T. pallidum crosses the blood-brain barrier has not been fully elucidated. Objectives: The primary purpose of this experimental design was to explore the effect of the T. pallidum adhesion protein Tp0751 on the blood-brain barrier and cerebrovascular endothelial cells. Methods: BEnd3 cells were used to construct a monolayer blood-brain barrier mode...