版权说明 操作指南
首页 > 成果 > 详情

Treponema pallidum Tp0751 alters the expression of tight junction proteins by promoting bEnd3 cell apoptosis and IL-6 secretion

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Lu, Simin;Wang, Jianye;He, Zhangping;He, Siqin;Zheng, Kang;...
通讯作者:
Wu, YM
作者机构:
[Wu, Yimou; Lu, Simin; He, Siqin; Yuan, Shuai; Wang, Jianye; He, Zhangping; Xu, Man] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pathogen Biol, Hengyang 421001, Peoples R China.
[Zheng, Kang] Southern Med Univ, Affiliated Hengyang Hosp, Hengyang Cent Hosp, Hengyang 421000, Hunan, Peoples R China.
[Wu, YM] 28 Changsheng West Rd, Hengyang, Hunan, Peoples R China.
通讯机构:
[Wu, YM ] 2
28 Changsheng West Rd, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
4 [5 (4 methyl 1 piperazinyl)[2,5' bi 1h benzimidazol] 2' yl]phenol;bacterial protein;caspase 3;caspase 8;caspase 9;interleukin 1beta;interleukin 6;occludin;protein ZO1;recombinant protein;tp0751 protein;tumor necrosis factor;unclassified drug;caspase 3;caspase 8;cytokine;interleukin 6;tight junction protein;animal cell;apoptosis;apoptosis rate;Article;bEnd.3 cell line;blood brain barrier;controlled study;cytokine release;electric resistance;enzyme activity;enzyme linked immunosorbent assay;flow cytometry;in vitro study;MAPK signaling;mouse;NF kB signaling;nonhuman;protein degradation;protein expression;real time polymerase chain reaction;staining;transcription regulation;transendothelial electrical resistance;translation regulation;Treponema pallidum;Western blotting;apoptosis;endothelium cell;human;metabolism;neurosyphilis;tight junction;Treponema;Apoptosis;Caspase 3;Caspase 8;Cytokines;Endothelial Cells;Humans;Interleukin-6;Neurosyphilis;Tight Junction Proteins;Tight Junctions;Treponema;Treponema pallidum
期刊:
International Journal of Medical Microbiology
ISSN:
1438-4221
年:
2022
卷:
312
期:
4
页码:
151553
基金类别:
The experiment was supported by the National Natural Science Foundation of China (Grant numbers 81471576 , 82002182 ).
机构署名:
本校为第一机构
院系归属:
医学院
药学与生物科学学院
摘要:
Background: Neurosyphilis is a serious complication caused by the invasion of the central nervous system by Treponema pallidum subsp. pallidum (T. pallidum). However, the molecular mechanism by which T. pallidum crosses the blood-brain barrier has not been fully elucidated. Objectives: The primary purpose of this experimental design was to explore the effect of the T. pallidum adhesion protein Tp0751 on the blood-brain barrier and cerebrovascular endothelial cells. Methods: BEnd3 cells were used to construct a monolayer blood-brain barrier mode...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com