Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE(-/-) mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Juan;Yang, Qin;Li, A-Fang;Li, Rong-Qing;Wang, Zuo;...

通讯作者：

Tang, Zhi-Han;Jiang, Zhi-Sheng;Wei, Dang-Heng

作者机构：

[Tang, Zhi-Han; Yang, Qin; Li, Rong-Qing; Wei, Dang-Heng; Peng, Juan; Li, A-Fang; Jiang, Zhi-Sheng; Ren, Zhong; Li, Guo-Hua; Tang, ZH; Jiang, ZS; Wang, Zuo; Liu, Lu-Shan] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, Calgary, AB, Canada.

[Zheng, Xi-Long] Univ South China, Dept Physiol, Hengyang, Prc, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Inst Neurosci, Sch Med, Hengyang, Prc, Peoples R China.

通讯机构：

[Tang, ZH; Jiang, ZS; Wei, DH] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Autophagy;Endothelial cells;Inflammation;Pathology Section;TET2

期刊：

Oncotarget

ISSN：

1949-2553

年：

2016

卷：

期：

页码：

76423-76436

DOI：

10.18632/oncotarget.13121

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370378, 81641019, 81670429, 81541005]; Key Project of Science and Technology Department of Hunan Province [2015JC3081, 2015SK2038]; Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [CQKLBST-2015-004]; Construct Program of the Key Discipline in Hunan Province; Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; Zhengxiang Scholar Program of University of South China [2014-004]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Tet methylcytosine dioxygenase 2 (TET2) mediates the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The loss of TET2 is associated with advanced atherosclerotic lesions. Our previous study showed that TET2 improves endothelial cell function by enhancing endothelial cell autophagy. Accordingly, this study determined the role of TET2 in atherosclerosis and potential mechanisms. In ApoE-/- mice fed high-fat diet, TET2 overexpression markedly decreased atherosclerotic lesions with uniformly increased level of 5hmC and decreased level of 5mC in genomic DNA. TET2 overexpress...

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Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE(-/-) mice

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