A Population-based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia

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成果类型：

期刊论文

作者：

Liu, Wen-Yue;Lian, Li-You;Zhang, Huai;Chen, Sui-Dan;Jin, Xin-Zhe;...

通讯作者：

Zheng, MH;Valenti, L

作者机构：

[Liu, Wen-Yue] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou 325000, Peoples R China.

[Liu, Wen-Yue] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou Key Lab Diabet Res, Wenzhou 325000, Peoples R China.

[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, Wenzhou 325000, Peoples R China.

[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.

[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Key Lab Diag & Treatment Dev Chron Liver Dis, Wenzhou, Zhejiang, Peoples R China.

通讯机构：

[Zheng, MH ] W

[Valenti, L ] U

Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.

Univ Milan, Dept Pathophysiol & Transplantat, Via Festa Perdono 7, I-20121 Milan, Italy.

语种：

英文

关键词：

Iron overload;Metabolic dysfunction-associated fatty liver disease;Metabolic hyperferritinemia;Metabolic syndrome

期刊：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ISSN：

0021-972X

年：

2023

DOI：

10.1210/clinem/dgad749

基金类别：

National Natural Science Foundation of China [82070588]; Project of New Century 551 Talent Nurturing in Wenzhou

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: There is limited data on the clinical significance of metabolic hyperferritinemia (MHF) based on the most recent consensus. We aimed to validate the clinical outcomes of MHF in general population and biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD) patients. METHODS: NHANES database and PERSONS cohort were included. MHF was defined as elevated serum ferritin with metabolic dysfunction (MD) and stratified into different grades according to ferritin (grade 1: 200 [females]/300 [males] - 550 ng/ml; grade 2: 5...

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A Population-based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia

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