Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiong, Shun;Liu, Zhaoping;Zhang, Xiaohong;Huang, Shaobin;Ding, Xuan;...

通讯作者：

Liu, Shuangquan;Zhao, FJ

作者机构：

[Zhou, Jie; Li, Weiwei; Liu, Shuangquan; Xiong, Shun; Zhao, Feijun; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Zhao, FJ; Yao, Jiangchen; Zhang, Xiaohong] Univ South China, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Jie; Li, Weiwei; Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.

[Liu, Shuangquan; Zhao, Feijun; Zhao, FJ] Univ South China, Affiliated Hosp 1, Inst Microbiol & Infect Dis, Hengyang Med Sch,Dept Clin Lab Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, SQ; Zhao, FJ ] U

Univ South China, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Inst Microbiol & Infect Dis, Hengyang Med Sch,Dept Clin Lab Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Syphilis;Treponema pallidum;Diagnosis;Vaccine;Drug resistance;Models

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2023

卷：

期：

页码：

1-19

DOI：

10.1186/s12967-023-04685-4

基金类别：

This work was supported by the National Natural Science Foundation of China (nos. 81971980), Major Scientific and Technological Projects for collaborative prevention and control of birth defects in Hunan Province (no. 2019SK1010), Hunan Province Natural Science Foundation (no. 2021JJ30604) and Key Project of Hunan Provincial Health Commission (no. 20221064723), Scientific Research and Innovation Project of postgraduates in Hunan Province (No. CX20220974).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal of research into clinical strategies for the disease, including diagnostic biomarkers and possible strategies for treatment and prevention. Although serological testing remains the predominant laboratory diagnostic method for syphilis, it is worth noting that investigations pertaining to the DNA of T. pallidum, non-coding RNAs (ncRNAs), chemokines, and metabolites in peripheral blood, c...

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Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models

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