Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer

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成果类型：

期刊论文

作者：

Chen, Shang;He, Yan;Huang, Xin;Shen, Yao;Zou, Qingshuang;...

通讯作者：

Liu, Quan;Luo, DX;Fu, L

作者机构：

[Huang, Xin; Chen, Shang; He, Yan; Yang, Gun; Shen, Yao; Luo, DX; Liu, Quan; Luo, Dixian] Shenzhen Univ, Huazhong Univ Sci & Technol, Dept Lab Med, Union Shenzhen Hosp,Nanshan Hosp, Shenzhen 518052, Peoples R China.

[Chen, Shang] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound,Med S, Shenzhen 518060, Peoples R China.

[He, Yan; Yang, Gun] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Huang, Xin] Anhui Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Hefei 230032, Peoples R China.

[Zou, Qingshuang] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China.

通讯机构：

[Luo, DX ; Liu, Q; Fu, L ] S

Shenzhen Univ, Huazhong Univ Sci & Technol, Dept Lab Med, Union Shenzhen Hosp,Nanshan Hosp, Shenzhen 518052, Peoples R China.

Shenzhen Univ, Hlth Sci Ctr, Dept Pharmacol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen 518055, Peoples R China.

Shenzhen Univ, Int Canc Ctr, Hlth Sci Ctr, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Liver cancer;Tumor-associated macrophage;Dual-targeting;Small interfering RNA;m6A reader YTHDF1

期刊：

Journal of Nanobiotechnology

ISSN：

1477-3155

年：

2024

卷：

期：

页码：

1-21

DOI：

10.1186/s12951-024-02612-3

基金类别：

This study was financially supported by the Shenzhen Nanshan District Science and Technology Project (Nos. NSZD2023038 and NSZD2023013), the General Projects of National Natural Science Foundation of China (No. 82272779), Guangdong basic and applied basic research foundation (No. 2023A1515030182), Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund (No. 2022A1515220042), National Natural Science Foundation of Shenzhen (Nos. 202308073002196, JCYJ20220530141609021 and JCYJ20220530141608020), Shenzhen Nanshan District Newly Introduced Discipline Leader Fund Project (No. NSZD2023020), 2023 International Science and Technology Independent Cooperation Project (No. GJHZ20220913144213025) and Shenzhen Medical Research Funds (No. A2301056).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Tumor-associated macrophages (TAMs) are a promising target for cancer immunotherapy, but delivering therapeutic agents to TAMs within the tumor microenvironment (TME) is challenging. In this study, a photosensitive, dual-targeting nanoparticle system (M.RGD@Cr-CTS-siYTHDF1 NPs) was developed. The structure includes a shell of DSPE-modified RGD peptides targeting integrin receptors on tumor cells and carboxymethyl mannose targeting CD206 receptors on macrophages, with a core of chitosan adsorbing m6A reading protein YTHDF1 siRNA and chromium nan...

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Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer

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