DNA-PKcs parylation regulates DNA-PK kinase activity in the DNA damage response

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成果类型：

期刊论文

作者：

Han, Yang;Jin, Feng;Xie, Ying;Liu, Yike;Hu, Sai;...

通讯作者：

Zhou, Ping-Kun;Ma, Teng

作者机构：

[Hu, Sai; Han, Yang] Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421001, Hunan, Peoples R China.

[Jin, Feng; Liu, Yike; Guan, Hua; Ma, Teng; Xie, Ying; Hu, Sai; Han, Yang; Gu, Yongqing; Liu, Xiao-Dan; Zhou, Ping-Kun] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

[Liu, Yike; Zhou, Ping-Kun] Guangzhou Med Univ, State Key Lab Resp Dis, Inst Chem Carcinogenesis, Guangzhou 511436, Guangdong, Peoples R China.

[Ma, Teng] Capital Med Univ, Beijing Chest Hosp, Dept Cellular & Mol Biol, Beijing TB & Thorac Tumor Res Inst, 2 Res Bldg,97 Machang, Beijing 101149, Peoples R China.

通讯机构：

[Zhou, Ping-Kun] B

[Ma, Teng] C

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

Capital Med Univ, Beijing Chest Hosp, Dept Cellular & Mol Biol, Beijing TB & Thorac Tumor Res Inst, 2 Res Bldg,97 Machang, Beijing 101149, Peoples R China.

语种：

英文

关键词：

DNA dependent protein kinase;nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1;nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 2;olaparib;poly(adenosine diphosphate ribose);protein kinase C;serine;DNA dependent protein kinase;nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1;PARP1 protein, human;PRKDC protein, human;Article;autophosphorylation;cell cycle G1 phase;cell cycle G2 phase;cell cycle S phase;cell proliferation;cell survival;cell synchronization;chromatin;colony formation;controlled study;DNA damage response;DNA end joining repair;enzyme active site;enzyme activity;female;flow cytometry;HeLa cell line;human;human cell;immunofluorescence;immunoprecipitation;ionizing radiation;parylation;protein modification;protein phosphorylation;radiosensitivity;regulatory mechanism;Western blotting;DNA damage;DNA repair;genetics;metabolism;neoplasm;poly(adenosine diphosphate) ribosylation;DNA Damage;DNA Repair;DNA-Activated Protein Kinase;HeLa Cells;Humans;Neoplasms;Poly (ADP-Ribose) Polymerase-1;Poly ADP Ribosylation

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2019

卷：

期：

页码：

3609-3616

DOI：

10.3892/mmr.2019.10640

基金类别：

The present study was supported by grants from the National Key Basic Research Program (973 Program) of MOST, China (grant no. 2015CB910601) and the National Natural Science Foundation of China (grant nos. 81530085, 31570853, 81602799, 31870847). The present study was supported by grants from the national Key Basic research Program (973 Program) of MoST, china (grant no. 2015cB910601) and the national natural Science Foundation of china (grant nos. 81530085, 31570853, 81602799, 31870847).

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

DNA- dependent protein kinase catalytic subunit (-PKcs) is the core protein involved in the non-homologous end-joining repair of double-strand breaks. In addition, it can form a complex with poly(AD P-ribose) polymerase 1 (PAR P1), which catalyzes protein PAR ylation. However, it is unclear how DNA- PKcs interacts with PAR P1 in the DNA damage response and how PAR ylation affects DNA- PK kinase activity. Using immunoprecipitation, immunofluorescence and flow cytometry the present study found that DNA-PKcs was PAR ylated after DNA damage, and th...

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DNA-PKcs parylation regulates DNA-PK kinase activity in the DNA damage response

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