DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Han, Yang;Jin, Feng;Xie, Ying;Liu, Yike;Hu, Sai;...

通讯作者：

Zhou, Ping-Kun;Ma, Teng

作者机构：

[Hu, Sai; Han, Yang] Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421001, Hunan, Peoples R China.

[Jin, Feng; Liu, Yike; Guan, Hua; Ma, Teng; Xie, Ying; Hu, Sai; Han, Yang; Gu, Yongqing; Liu, Xiao-Dan; Zhou, Ping-Kun] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

[Liu, Yike; Zhou, Ping-Kun] Guangzhou Med Univ, State Key Lab Resp Dis, Inst Chem Carcinogenesis, Guangzhou 511436, Guangdong, Peoples R China.

[Ma, Teng] Capital Med Univ, Beijing Chest Hosp, Dept Cellular & Mol Biol, Beijing TB & Thorac Tumor Res Inst, 2 Res Bldg,97 Machang, Beijing 101149, Peoples R China.

通讯机构：

[Zhou, Ping-Kun] B

[Ma, Teng] C

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

Capital Med Univ, Beijing Chest Hosp, Dept Cellular & Mol Biol, Beijing TB & Thorac Tumor Res Inst, 2 Res Bldg,97 Machang, Beijing 101149, Peoples R China.

语种：

英文

关键词：

parylation;double strand break repair;non-homologous end joining repair;autophosphorylation

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2019

卷：

期：

页码：

3609-3616

DOI：

10.3892/mmr.2019.10640

基金类别：

National Key Basic Research Program (973 Program) of MOST, China [2015CB910601]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81530085, 31570853, 81602799, 31870847]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

DNA-dependent protein kinase catalytic subunit (-PKcs) is the core protein involved in the non-homologous end-joining repair of double-strand breaks. In addition, it can form a complex with poly(ADP-ribose) polymerase 1 (PARP1), which catalyzes protein PARylation. However, it is unclear how DNA-PKcs interacts with PARP1 in the DNA damage response and how PARylation affects DNA-PK kinase activity. Using immunoprecipitation, immunofluorescence and flow cytometry the present study found that DNA-PKcs was PARylated after DNA damage, and the PARP1/2 inhibitor olaparib completely abolished DNA-PKcs ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问